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- Table of Contents
IFITM3 Antibodies
AND IFITM3 ELISA kits, IFITM3 Proteins
Many biological assays use antibodies to detect IFITM3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IFITM3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IFITM3 antibodies...
Designing a Western blot for IFITM3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IFITM3 Western Blot GuideIFITM3 Infographic by Boster Bio
All IFITM3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M02265-2
20μL, 40μL, 100μL, 200μL
Cat # M02265-2
20μL, 40μL, 100μL, 200μL
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M02265
100 μl
Cat # M02265
100 μl
IFITM3 Overview
Facts about Interferon-induced transmembrane protein 3.
Interferon-induced transmembrane protein 3 (IFITM3)
IFN-induced antiviral protein that disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses into the host cell cytoplasm by preventing viral combination with cholesterol depleted endosomes.
May inactivate new enveloped viruses that buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV).
Gene Information
| Human | |
|---|---|
| Gene Name: | IFITM3 |
| Uniprot: | Q01628 |
| Entrez: | 10410 |
Family
| Belongs to: |
|---|
| CD225/Dispanin family |
Alternative Names
1-8U; Fragilis; IFITM3; interferon induced transmembrane protein 3 (1-8U); interferon-induced transmembrane protein 3; Interferon-inducible protein 1-8U; IP15; mil-1
Molecular Weight
Mass (kDA):
14.632 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.5 |
| Sequence: | 11; NC_000011.10 (319676..320860, complement) |
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein.
Diseases
- Influenza
- Virus Diseases
- Neoplasms
- Malignant Neoplasms
- Tissue Adhesions
- Infective Disorder
- Hepatitis
- Malignant Tumor Of Colon
- Carcinoma
- Hepatitis C
- Inflammation
- West Nile Viral Infection
- Ulcer
Interacting Proteins
- NAMPT
Pathways
- Cell Adhesion
- Immune Response
- Cell Development
- Localization
- Germ Cell Development
- Pathogenesis
- Cell Proliferation
- Cell Differentiation
- Viral Replication
- Innate Immune Response
- Methylation
- Cell Growth
- Transport
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IFITM3
bosterbio.com/bosterbio-gene-info-cards/IFITM3
References
PMID: 1906403 by Lewin A.R., et al. Molecular analysis of a human interferon-inducible gene family.
PMID: 22446628 by Everitt A.R., et al. IFITM3 restricts the morbidity and mortality associated with influenza.