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- Table of Contents
IL6ST Antibodies
AND IL6ST ELISA kits, IL6ST Proteins
Many biological assays use antibodies to detect IL6ST, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IL6ST in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IL6ST antibodies...
Designing a Western blot for IL6ST? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IL6ST Western Blot GuideIL6ST Infographic by Boster Bio
All IL6ST Products
Product
Figures
Specificity
Applications
Price
Human Gp130/IL6ST ELISA Kit PicoKine®
3 Citations
Human
ELISA
$499
Cat # EK0367
96 wells/kit, with removable strips.
Cat # EK0367
96 wells/kit, with removable strips.
Mouse Gp130/IL6ST ELISA Kit PicoKine®
1 Citations
Mouse
ELISA
$499
Cat # EK0577
96 wells/kit, with removable strips.
Cat # EK0577
96 wells/kit, with removable strips.
Rat IL6ST ELISA Kit PicoKine®
1 Citations
Rat
ELISA
$499
Cat # EK1742
96 wells/kit, with removable strips.
Cat # EK1742
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # FEK0577
96 wells/kit, with removable strips.
Cat # FEK0577
96 wells/kit, with removable strips.
Human, Mouse
IF, IHC, WB
$380
Cat # A01216S782-1
100ul
Cat # A01216S782-1
100ul
IL6ST Overview
Facts about Interleukin-6 receptor subunit beta.
Interleukin-6 receptor subunit beta (IL6ST)
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can use IL6ST for initiating signal transmission.
Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). This causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003).
Gene Information
| Human | |
|---|---|
| Gene Name: | IL6ST |
| Uniprot: | P40189 |
| Entrez: | 3572 |
Family
| Belongs to: |
|---|
| type I cytokine receptor family |
Alternative Names
CD130 antigen; CD130; CDw130; DKFZp564F053; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6RB; IL-6R-beta; IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor); interleukin receptor beta chain; interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; membrane glycoprotein gp130; Oncostatin-M receptor subunit alpha
Molecular Weight
Mass (kDA):
103.537 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q11.2 |
| Sequence: | 5; NC_000005.10 (55935095..55994963, complement) |
Tissue Specificity
Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
Diseases
- Leukemia
- Inflammation
- Neoplasms
- Janiceps
- Malignant Neoplasms
- Multiple Myeloma
- Carcinoma
- Liver Carcinoma
- Hypertrophy
- Nervousness
- Arthritis
- Malignant Paraganglionic Neoplasm
- Heart Failure
Interacting Proteins
- CNTF
- JAK1
- KCNIP3
- LIF
- OSM
- OSMR
- Stat3
Pathways
- Cell Proliferation
- Secretion
- Cell Growth
- Pathogenesis
- Cell Differentiation
- Cell Cycle
- Regeneration
- Immune Response
- Cell Death
- Inflammatory Response
- Localization
- Liver Regeneration
- Bone Resorption
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
- Glycosylation
- Iodination
- Reduction
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL6ST
bosterbio.com/bosterbio-gene-info-cards/IL6ST
References
PMID: 2261637 by Hibi M., et al. Molecular cloning and expression of an IL-6 signal transducer, gp130.
PMID: 10880057 by Tanaka M., et al. Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis.
2 Publications of Boster IL6ST Antibodies & ELISA Kits
- PubMed ID: 10.1097/SHK.0000000000000714, Interleukin-1 Receptor 2: A New Biomarker for Sepsis Diagnosis and Gram-Negative...
- PubMed ID: 10.1016/j.exer.2019.02.012, The bidirectional crosstalk between metastatic uveal melanoma cells and hepatic ...
*More publications can be found for each product on its corresponding product page