This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
KDM3A Antibodies
AND KDM3A ELISA kits, KDM3A Proteins
Many biological assays use antibodies to detect KDM3A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KDM3A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KDM3A antibodies...
Designing a Western blot for KDM3A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the KDM3A Western Blot GuideKDM3A Infographic by Boster Bio
All KDM3A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, IP, IF, IHC, ICC, WB
$370
Cat # A03994-2
100 μl/vial
Cat # A03994-2
100 μl/vial
Human
$960
Cat # LS055818
20 µg, 100 µg
Cat # LS055818
20 µg, 100 µg
KDM3A Overview
Facts about Lysine-specific demethylase 3A.
Lysine-specific demethylase 3A (KDM3A)
Histone demethylase that especially demethylates'Lys- 9' of histone H3, thereby playing a fundamental role in histone code. Preferentially demethylates mono- and dimethylated H3'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3'Lys-9'.
Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by engaging in recruitment to androgen-receptor target genes, resulting in H3'Lys-9' demethylation and transcriptional activation.
Gene Information
| Human | |
|---|---|
| Gene Name: | KDM3A |
| Uniprot: | Q9Y4C1 |
| Entrez: | 55818 |
Family
| Belongs to: |
|---|
| JHDM2 histone demethylase family |
Alternative Names
EC 1.14.11; EC 1.14.11.-; JHDM2A; JHDM2AJMJD1AJHMD2A; JmjC domain-containing histone demethylation protein 2A; JMJD1; JMJD1A; jumonji C domain-containing histone demethylase 2A; jumonji domain containing 1; jumonji domain containing 1A; Jumonji domain-containing protein 1A; KDM3A; KIAA0742; KIAA0742DKFZp686A24246; Lysine (K)specific Demethylase 3A; Lysine (K)-specific Demethylase 3A; lysine-specific demethylase 3A; testis-specific protein A; TSGA; TSGADKFZp686P07111
Molecular Weight
Mass (kDA):
147.341 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p11.2 |
| Sequence: | 2; NC_000002.12 (86440647..86492716) |
Subcellular Localizations
Cytoplasm. Nucleus. Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity).
Diseases
- Malignant Neoplasms
- Hypoxia
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Kidney
- Malignant Tumor Of Colon
- Carcinogenesis
- Anoxia
- Obesity
- Kidney Neoplasm
- Infertility
- Malignant Neoplasm Of Lung
- Tumor Angiogenesis
Interacting Proteins
- RPS6KA5
Pathways
- Methylation
- Demethylation
- Histone Methylation
- Spermatogenesis
- Histone Modification
- Response To Hypoxia
- Cell Differentiation
- Dna Methylation
- Histone Demethylation
- Gene Silencing
- Histone Lysine Methylation
- Cell Development
- Localization
PTMs
- Methylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KDM3A
bosterbio.com/bosterbio-gene-info-cards/KDM3A
References
PMID: 16603237 by Yamane K., et al. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.
PMID: 28262558 by Tumber A., et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.