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- Table of Contents
Kit ligand Antibodies
AND KITLG ELISA kits, Kit ligand Proteins
Many biological assays use antibodies to detect Kit ligand, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kit ligand in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kit ligand antibodies...
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KITLG Infographic by Boster Bio
All KITLG Products
Product
Figures
Specificity
Applications
Price
Rat SCF/KITLG/Kit ligand ELISA Kit PicoKine®
1 Citations 5 Q&As
Rat
ELISA
$499
Cat # EK0508
96 wells/kit, with removable strips.
Cat # EK0508
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # EK0507
96 wells/kit, with removable strips.
Cat # EK0507
96 wells/kit, with removable strips.
Mouse SCF/KITLG/Kit ligand ELISA Kit PicoKine®
3 Citations 10 Q&As
Mouse
ELISA
$499
Cat # EK0509
96 wells/kit, with removable strips.
Cat # EK0509
96 wells/kit, with removable strips.
SDS-PAGE, Bioactivity
$300
Cat # PROTP20826
Starting from 10ug
Cat # PROTP20826
Starting from 10ug
Human
IHC, WB
$523
Cat # M01254-1
100 µl
Cat # M01254-1
100 µl
KITLG Overview
Facts about Kit ligand.
Kit ligand (KITLG)
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an important role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell growth, function and migration, and in melanogenesis.
KITLG/SCF binding may activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of this kinase AKT1.
Gene Information
| Human | |
|---|---|
| Gene Name: | KITLG |
| Uniprot: | P21583 |
| Entrez: | 4254 |
Family
| Belongs to: |
|---|
| SCF family |
Alternative Names
c-kit Ligand; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; KIT ligand; Kitl; KITLG; KL-1; Mast cell growth factor; MGF; MGFSHEP7; SCF; SCFStem cell factor; SFc-Kit ligand; SHEP7; SLF; steel factor
Molecular Weight
Mass (kDA):
30.899 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q21.32 |
| Sequence: | 12; NC_000012.12 (88492793..88580473, complement) |
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium. Cell projection, filopodium.; [Soluble KIT ligand]: Secreted.
Diseases
- Neoplasms
- Malignant Neoplasms
- Germ Cell Tumor
- Testicular Neoplasms
- Malignant Neoplasm Of Testis
- Neoplasms, Germ Cell And Embryonal
- Testicular Germ Cell Tumor
- Infertility
- Male Infertility
- Malignant Paraganglionic Neoplasm
- Malignant Germ Cell Tumor
- Carcinoma
Interacting Proteins
- KIT
Pathways
- Pigmentation
- Pathogenesis
- Cell Proliferation
- Localization
- Spermatogenesis
- Methylation
- Cell Migration
- Dna Packaging
- Lactation
- Eye Pigmentation
- Cell Development
- Dna Methylation
- Oocyte Growth
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KITLG
bosterbio.com/bosterbio-gene-info-cards/KITLG
References
PMID: 2208279 by Martin F.H., et al. Primary structure and functional expression of rat and human stem cell factor DNAs.
PMID: 1724381 by Anderson D.M., et al. Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24.
7 Publications of Boster Kit ligand Antibodies & ELISA Kits
- PubMed ID: 10.3892/mmr.2018.8776, Tranilast prevents renal interstitial fibrosis by blocking mast cell infiltratio...
- PubMed ID: 10.3389/fimmu.2017.00147, GM-CSF Inhibits c-Kit and SCF Expression by Bone Marrow-Derived Dendritic Cells
- PubMed ID: 10.1371/journal.pone.0238209, Ilomastat contributes to the survival of mouse after irradiation via promoting t...
- PubMed ID: 29246405, Selective tropism of liver stem cells to hepatocellular carcinoma in vivo.
- PubMed ID: 28261209, GM-CSF Inhibits c-Kit and SCF Expression by Bone Marrow-Derived Dendritic Cells
- PubMed ID: 28033308, Effects of Polysaccharide of Gastrodia Elata Blume and Electro-Acupuncture on Ex...
- PubMed ID: 17657848, Selective tropism of liver stem cells to hepatocellular carcinoma in vivo.
*More publications can be found for each product on its corresponding product page