Low-density lipoprotein receptor-related protein 8 (LRP8)

LRP8 participates in distributing the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to modulate DAB1 tyrosine phosphorylation and microtubule function in neurons.

LRP8 has greater affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development.