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- Table of Contents
LRP8 Antibodies
AND LRP8 ELISA kits, LRP8 Proteins
Many biological assays use antibodies to detect LRP8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LRP8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LRP8 antibodies...
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LRP8 Infographic by Boster Bio
All LRP8 Products
Product
Figures
Specificity
Applications
Price
Anti-ApoER2/LRP8 Antibody Picoband®
2 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03444-2
100 μg/vial
Cat # A03444-2
100 μg/vial
LRP8 Overview
Facts about Low-density lipoprotein receptor-related protein 8.
Low-density lipoprotein receptor-related protein 8 (LRP8)
LRP8 participates in distributing the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to modulate DAB1 tyrosine phosphorylation and microtubule function in neurons.
LRP8 has greater affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development.
Gene Information
| Human | |
|---|---|
| Gene Name: | LRP8 |
| Uniprot: | Q14114 |
| Entrez: | 7804 |
Family
| Belongs to: |
|---|
| LDLR family |
Alternative Names
ApoER2; APOER2HSZ75190; Apolipoprotein E R2; Apolipoprotein E receptor 2; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; low-density lipoprotein receptor-related protein 8; Lr8b; LRP8; LRP-8; MCI1
Molecular Weight
Mass (kDA):
105.634 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p32.3 |
| Sequence: | 1; NC_000001.11 (53242364..53328070, complement) |
Tissue Specificity
Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Secreted. Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment.
Diseases
- Infarction
- Myocardial Infarction
- Alzheimer's Disease
- Coronary Artery Disease
- Atherosclerosis
- Thrombosis
- Malignant Neoplasms
- Nervousness
- Schizophrenia
- Tissue Adhesions
- Neoplasms
- Hemorrhage
Interacting Proteins
- APC
- APOE
- KDR
- Reln
Pathways
- Transport
- Platelet Activation
- Platelet Aggregation
- Endocytosis
- Brain Development
- Cholesterol Efflux
- Hemostasis
- Lipid Transport
- Ovulation
- Cholesterol Homeostasis
- Secretion
- Response To Lipopolysaccharide
- Cell Migration
PTMs
- Phosphorylation
Research Areas
- Alzheimers Research
- Lipid and Metabolism
- Neurodegeneration
- Neuronal Cell Markers
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LRP8
bosterbio.com/bosterbio-gene-info-cards/LRP8
References
PMID: 8626535 by Kim D.-H., et al. Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain.
PMID: 9079678 by Kim D.-H., et al. Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene.
1 Publications of Boster LRP8 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.anireprosci.2012.09.008, Effects of maternal and dietary selenium (Se-enriched yeast) on the expression o...
*More publications can be found for each product on its corresponding product page