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- Table of Contents
Designing an IHC experiment for Transcription factor Maf? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MAF IHC Guide2 Citations
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Facts about Transcription factor Maf.
Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters resulting in up-regulation of crystallin gene during lens fiber cell differentiation. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression.
| Human | |
|---|---|
| Gene Name: | MAF |
| Uniprot: | O75444 |
| Entrez: | 4094 |

| Belongs to: |
|---|
| bZIP family |

Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; CCA4; c-maf proto-oncogene; cMaf; c-Maf; MAF2; MGC71685; Proto-oncogene c-Maf; T lymphocyte c-maf long form; transcription factor Maf; v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog; v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian); V-maf musculoaponeurotic fibrosarcoma oncogene homolog
Mass (kDA):
38.492 kDA

| Human | |
|---|---|
| Location: | 16q23.2 |
| Sequence: | 16; NC_000016.10 (79202624..79601952, complement) |
Expressed in endothelial cells.
Nucleus.





PMID: 9616139 by Chesi M., et al. Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma.
PMID: 12149651 by Dhakshinamoorthy S., et al. c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction.