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- Table of Contents
Facts about Transcription factor Maf.
Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters resulting in up-regulation of crystallin gene during lens fiber cell differentiation. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression.
| Human | |
|---|---|
| Gene Name: | MAF |
| Uniprot: | O75444 |
| Entrez: | 4094 |

| Belongs to: |
|---|
| bZIP family |

Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; CCA4; c-maf proto-oncogene; cMaf; c-Maf; MAF2; MGC71685; Proto-oncogene c-Maf; T lymphocyte c-maf long form; transcription factor Maf; v-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog; v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian); V-maf musculoaponeurotic fibrosarcoma oncogene homolog
Mass (kDA):
38.492 kDA

| Human | |
|---|---|
| Location: | 16q23.2 |
| Sequence: | 16; NC_000016.10 (79202624..79601952, complement) |
Expressed in endothelial cells.
Nucleus.





PMID: 9616139 by Chesi M., et al. Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma.
PMID: 12149651 by Dhakshinamoorthy S., et al. c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction.