This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
MAP3K2 Antibodies
AND MAP3K2 ELISA kits, MAP3K2 Proteins
Many biological assays use antibodies to detect MAP3K2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP3K2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP3K2 antibodies...
Designing a Western blot for MAP3K2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MAP3K2 Western Blot GuideMAP3K2 Infographic by Boster Bio
All MAP3K2 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # A02354-1
100 μg/vial
Cat # A02354-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02354
100 μl
Cat # M02354
100 μl
Human
ELISA
$480
Cat # EKC1852
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1852
1 kit, containing one 96-well plate and all necessary reagents
MAP3K2 Overview
Facts about Mitogen-activated protein kinase kinase kinase 2.
Mitogen-activated protein kinase kinase kinase 2 (MAP3K2)
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity).
Plays a role in caveolae kiss-and-run dynamics. .
Gene Information
| Human | |
|---|---|
| Gene Name: | MAP3K2 |
| Uniprot: | Q9Y2U5 |
| Entrez: | 10746 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11.25; MAP/ERK kinase kinase 2; MAP3K2; MAPK/ERK kinase kinase 2; MAPKKK2; MEK kinase 2; MEKK 2; MEKK2; MEKK2B; mitogen-activated protein kinase kinase kinase 2
Molecular Weight
Mass (kDA):
69.741 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q14.3 |
| Sequence: | 2; NC_000002.12 (127298668..127388465, complement) |
Subcellular Localizations
Cytoplasm. Nucleus. Upon EGF stimulation, translocates into the nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Prostatic Neoplasms
- Inflammation
- Malignant Neoplasm Of Prostate
- Cell Transformation, Neoplastic
- Hypertensive Disease
- Cholangiocarcinoma
- Fracture Of First Cervical Vertebra
- Embryonal Carcinoma
- Malignant Neoplasm Of Breast
Interacting Proteins
- SFN
- STUB1
Pathways
- Cell Proliferation
- Cytokine Production
- Cell Activation
- T Cell Activation
- Immune Response
- Cell Death
- Cell Growth
- Mast Cell Cytokine Production
- Regulation Of Signal Transduction
- Proteolysis
- Adaptive Immune Response
- Keratinocyte Differentiation
- Sensitization
PTMs
- Phosphorylation
- Ubiquitination
Research Areas
- Angiogenesis
- Autophagy
- Cancer
- Mitophagy
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP3K2
bosterbio.com/bosterbio-gene-info-cards/MAP3K2
References
PMID: 10713157 by Cheng J., et al. Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation.
PMID: 15075238 by Raviv Z., et al. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.
1 Publications of Boster MAP3K2 Antibodies & ELISA Kits
- PubMed ID: 25304384, Li Y, Zhang Z, Zhou X, Li L, Liu Q, Wang Z, Bai X, Zhao Y, Shi H, Zhang X, Ye L....
*More publications can be found for each product on its corresponding product page