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- Table of Contents
MCU Antibodies
AND MCU ELISA kits, MCU Proteins
Many biological assays use antibodies to detect MCU, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MCU in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MCU antibodies...
Designing a Western blot for MCU? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MCU Western Blot GuideDesigning an IHC experiment for MCU? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MCU IHC GuideMCU Infographic by Boster Bio
All MCU Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00685-1
100 μg/vial
Cat # A00685-1
100 μg/vial
MCU Overview
Facts about Calcium uniporter protein, mitochondrial.
Calcium uniporter protein, mitochondrial (MCU)
Mitochondrial inner membrane calcium uniporter which mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363).
Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down- regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 raises MCU action (PubMed:24560927, PubMed:26903221).
Gene Information
| Human | |
|---|---|
| Gene Name: | MCU |
| Uniprot: | Q8NE86 |
| Entrez: | 90550 |
Family
| Belongs to: |
|---|
| MCU (TC 1.A.77) family |
Alternative Names
C10orf42; coiled-coil domain containing 109A; coiled-coil domain-containing protein 109A; FLJ46135
Molecular Weight
Mass (kDA):
39.867 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q22.1 |
| Sequence: | 10; NC_000010.11 (72692131..72887694) |
Subcellular Localizations
Mitochondrion inner membrane; Multi-pass membrane protein.
Diseases
- Gastroesophageal Reflux Disease
- Vesico-ureteral Reflux
- Urinary Tract Infection
- Urethral Diseases
- Pathological Dilatation
- Infective Disorder
- Cicatrix
- Hydronephrosis
- Stenosis
- Kidney Diseases
- Urologic Diseases
- Urethral Obstruction
- Urethral Stricture
Interacting Proteins
- MCUR1
- MICU1
Pathways
- Micturition
- Transport
- Cell Death
- Pathogenesis
- Oxidative Phosphorylation
- Localization
- Programmed Cell Death
- Uniport
- Insulin Secretion
- Excretion
- Secretion
- Mitochondrial Depolarization
- Carbohydrate Utilization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MCU
bosterbio.com/bosterbio-gene-info-cards/MCU
References
PMID: 21685888 by De Stefani D., et al. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.
PMID: 21685886 by Baughman J.M., et al. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.