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- Table of Contents
MMP14 Antibodies
AND MMP14 ELISA kits, MMP14 Proteins
Many biological assays use antibodies to detect MMP14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MMP14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MMP14 antibodies...
Designing a Western blot for MMP14? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MMP14 Western Blot GuideDesigning an IHC experiment for MMP14? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MMP14 IHC GuideMMP14 Infographic by Boster Bio
All MMP14 Products
Product
Figures
Specificity
Applications
Price
Anti-MMP14/Mt1 Mmp Rabbit Monoclonal Antibody
3 Citations
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00656
100 μl
Cat # M00656
100 μl
Human, Mouse, Rat
IHC, WB
$370
Cat # PA2147
100 μg/vial
Cat # PA2147
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1376
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1376
1 kit, containing one 96-well plate and all necessary reagents
MMP14 Overview
Facts about Matrix metalloproteinase-14.
Matrix metalloproteinase-14 (MMP14)
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A.
Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484).
Gene Information
| Human | |
|---|---|
| Gene Name: | MMP14 |
| Uniprot: | P50281 |
| Entrez: | 4323 |
Family
| Belongs to: |
|---|
| peptidase M10A family |
Alternative Names
EC 3.4.24; EC 3.4.24.80; matrix metallopeptidase 14 (membrane-inserted); matrix metalloproteinase 14 (membrane-inserted); matrix metalloproteinase-14; membrane type 1 metalloprotease; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase; MMP14; MMP-14; MMP-X1; MT1MMP; MT1-MMP; MT1-MMPMTMMP1; MT-MMP 1; MT-MMP1
Molecular Weight
Mass (kDA):
65.894 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q11.2 |
| Sequence: | 14; NC_000014.9 (22836585..22847758) |
Tissue Specificity
Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.
Subcellular Localizations
Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Invasion
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Carcinoma
- Tumor Angiogenesis
- Mammary Neoplasms
- Tissue Adhesions
- Malignant Neoplasm Of Breast
- Pathologic Neovascularization
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- ADI1
- BCAR1
- CCDC155
- FGFR4
- FURIN
- Gorasp2
- LIMK1
- LUM
- TIMP2
Pathways
- Cell Migration
- Angiogenesis
- Proteolysis
- Localization
- Cell Adhesion
- Cell Proliferation
- Pathogenesis
- Cell Growth
- Cell Motility
- Tissue Remodeling
- Secretion
- Rna Interference
- Regeneration
PTMs
- Cleavage
- Phosphorylation
- Methylation
- Demethylation
- Biotinylation
- Glycosylation
Research Areas
- Cancer
- Extracellular Matrix
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MMP14
bosterbio.com/bosterbio-gene-info-cards/MMP14
References
PMID: 8015608 by Sato H., et al. A matrix metalloproteinase expressed on the surface of invasive tumour cells.
PMID: 7721107 by Takino T., et al. Cloning of a human gene potentially encoding a novel matrix metalloproteinase having a C-terminal transmembrane domain.
10 Publications of Boster MMP14 Antibodies & ELISA Kits
- PubMed ID: 29393353, Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK...
- PubMed ID: 27453531, The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-?1 p...
- PubMed ID: 27882817, Yan Li, Lin Li, Ou Zeng, Jun Mao Liu & Jun Yang H2S improves renal fibrosis in S...
- PubMed ID: 24628713, Zhang Jt, Sun W, Zhang Wz, Ge Cy, Liu Zy, Zhao Zm, Lu Xs, Fan Yz. Bmc Cancer. 20...
- PubMed ID: 24765144, Zhou H, Wu A, Fu W, Lv Z, Zhang Z. Oncol Lett. 2014 May;7(5):1395-1400. Epub 201...
- PubMed ID: 20579139, Dong Q, Yu D, Yang Cm, Jiang B, Zhang H. Int J Exp Pathol. 2010 Aug;91(4):368-73...
- PubMed ID: 25673203, Shi Ch, Wang Ws, Zhang Zd, Li Cj, Guo Fj, Li F, Chen Am. J Huazhong Univ Sci Tec...
- PubMed ID: 24573354, Xiao H, Li H, Yu G, Xiao W, Hu J, Tang K, Zeng J, He W, Zeng G, Ye Z, Xu H. Onco...
- PubMed ID: 23058919, Jin F, Jiang S, Yang D, Zhang X, Yang Y, Zhang Y, Li K, Yang Y, Ma S. Biochem Bi...
- PubMed ID: 23795739, Jiang S, Jin F, Li D, Zhang X, Yang Y, Yang D, Li K, Yang Y, Ma S. High Alt Med ...
*More publications can be found for each product on its corresponding product page