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- Table of Contents
Major vault protein Antibodies
AND MVP ELISA kits, Major vault protein Proteins
Many biological assays use antibodies to detect Major vault protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Major vault protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Major vault protein antibodies...
Designing a Western blot for Major vault protein? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MVP Western Blot GuideDesigning an IHC experiment for Major vault protein? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MVP IHC GuideMVP Infographic by Boster Bio
All MVP Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A00643-3
100 μg/vial
Cat # A00643-3
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00642-1
100 μg/vial
Cat # M00642-1
100 μg/vial
Human, Mouse
Flow Cytometry, IHC, WB
$370
Cat # M00664-2
100 μg/vial
Cat # M00664-2
100 μg/vial
Human, Mouse
IHC, WB
$370
Cat # M00664-1
100 μg/vial
Cat # M00664-1
100 μg/vial
Human, Mouse
Flow Cytometry, IHC, WB
$370
Cat # M00664-3
100 μg/vial
Cat # M00664-3
100 μg/vial
MVP Overview
Facts about Major vault protein.
Major vault protein (MVP)
Required for normal vault construction. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction.
Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK.
Gene Information
| Human | |
|---|---|
| Gene Name: | MVP |
| Uniprot: | Q14764 |
| Entrez: | 9961 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
LRPVAULT1; Lung resistance-related protein; major vault protein
Molecular Weight
Mass (kDA):
99.327 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p11.2 |
| Sequence: | 16; NC_000016.10 (29820394..29848039) |
Tissue Specificity
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
Subcellular Localizations
Cytoplasm. Nucleus, nuclear pore complex. Cytoplasm, perinuclear region. 5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
Diseases
- Mitral Valve Prolapse Syndrome
- Blepharoptosis
- Malignant Neoplasms
- Mitral Valve Insufficiency
- Regurgitation
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Non-small Cell Lung Carcinoma
- Neoplasms
- Cardiac Arrhythmia
- Carcinoma
- Endocarditis
- Heart Diseases
Pathways
- Drug Resistance
- Transport
- Localization
- Pathogenesis
- Angiogenesis
- Reflex
- Micturition
- Cell Cycle
- Drug Transport
- Cell Proliferation
- Immune Response
- Virulence
- Intracellular Transport
PTMs
- Phosphorylation
- Methylation
- Dephosphorylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MVP
bosterbio.com/bosterbio-gene-info-cards/MVP
References
PMID: 7585126 by Scheffer G.L., et al. The drug resistance-related protein LRP is the human major vault protein.
PMID: 11071864 by Lange C., et al. Cloning and initial analysis of the human multidrug resistance- related MVP/LRP gene promoter.