- Table of Content
Following activation by ligand, interacts with GRB2 or PLCG2 and causes phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment.
|protein kinase superfamily|
|Sequence:||2; NC_000002.12 (111898607..112029561)|
Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.
Membrane; Single-pass type I membrane protein.
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