NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

As the sensor part of the NLRP3 inflammasome, plays an essential role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the creation of the inflammasome polymeric complex, made from NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5).

Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1- catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu (PubMed:28847925). Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494).