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- Table of Contents
NR5A2 Antibodies
AND NR5A2 ELISA kits, NR5A2 Proteins
Many biological assays use antibodies to detect NR5A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NR5A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NR5A2 antibodies...
Designing a Western blot for NR5A2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NR5A2 Western Blot GuideDesigning an IHC experiment for NR5A2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NR5A2 IHC GuideNR5A2 Infographic by Boster Bio
All NR5A2 Products
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NR5A2 Overview
Facts about Nuclear receptor subfamily 5 group A member 2.
Nuclear receptor subfamily 5 group A member 2 (NR5A2)
Nuclear receptor that acts as a key metabolic sensor by modulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Along with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism.
Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a crucial cis-element of their expression and regulation.
Gene Information
| Human | |
|---|---|
| Gene Name: | NR5A2 |
| Uniprot: | O00482 |
| Entrez: | 2494 |
Family
| Belongs to: |
|---|
| nuclear hormone receptor family |
Alternative Names
Alpha-1-fetoprotein transcription factor; B1-binding factor; b1-binding factor, hepatocyte transcription factor which activates enhancer IIof hepatitis B virus; B1F; B1F2; fetoprotein-alpha 1 (AFP) transcription factor; FTFLRH1; FTZ-F1 beta; FTZ-F1; FTZ-F1beta; HB1F; hB1F-2; hB1FCYP7A promoter-binding factor; Hepatocytic transcription factor; Liver receptor homolog 1; liver receptor homolog-1; LRH1; LRH-1; LRH-1CPF; NR5A2; nuclear receptor NR5A2; nuclear receptor subfamily 5 group A member 2; nuclear receptor subfamily 5, group A, member 2
Molecular Weight
Mass (kDA):
61.331 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.1 |
| Sequence: | 1; NC_000001.11 (200027710..200177424) |
Tissue Specificity
Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Pituitary Diseases
- Carcinoma
- Mammary Neoplasms
- Hepatitis B
- Hepatitis
- Liver Carcinoma
- Inflammation
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Pancreas
- Pancreatic Neoplasm
Interacting Proteins
- CTNNB1
- EDF1
- NCOA2
- NR0B2
- PROX1
Pathways
- Cholesterol Homeostasis
- Transport
- Cell Proliferation
- Cell Differentiation
- Localization
- Cholesterol Transport
- Reverse Cholesterol Transport
- Rna Interference
- Ovulation
- Cell Cycle
- Secretion
- Pathogenesis
- Granulosa Cell Differentiation
PTMs
- Cleavage
- Sumoylation
- Phosphorylation
Research Areas
- Chromatin Research
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR5A2
bosterbio.com/bosterbio-gene-info-cards/NR5A2
References
PMID: 9786908 by Li M., et al. Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus.
PMID: 10359768 by Nitta M., et al. CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene.
1 Publications of Boster NR5A2 Antibodies & ELISA Kits
- PubMed ID: 21134435, Zhao W, Wen Hx, Zheng Hl, Sun Sx, Sun Dj, Ni J. J Ethnopharmacol. 2011 Mar 8;134...
*More publications can be found for each product on its corresponding product page