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- Table of Contents
NOTCH1 Antibodies
AND NOTCH1 ELISA kits, NOTCH1 Proteins
Many biological assays use antibodies to detect NOTCH1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NOTCH1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NOTCH1 antibodies...
Designing a Western blot for NOTCH1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NOTCH1 Western Blot GuideDesigning an IHC experiment for NOTCH1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NOTCH1 IHC GuideNOTCH1 Infographic by Boster Bio
All NOTCH1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK1619
96 wells/kit, with removable strips.
Cat # EK1619
96 wells/kit, with removable strips.
Anti-Notch1 Monoclonal Antibody
2 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00033
100 μl
Cat # M00033
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00033-4
20μL, 40μL, 100μL, 200μL
Cat # M00033-4
20μL, 40μL, 100μL, 200μL
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00033-3
100 μg
Cat # M00033-3
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00033-2
100 μg
Cat # M00033-2
100 μg
Human, Mouse, Rat
ELISA
$540
Cat # EKC2622
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2622
1 kit, containing two 96-well plates and all necessary reagents
NOTCH1 Overview
Facts about Neurogenic locus notch homolog protein 1.
Neurogenic locus notch homolog protein 1 (NOTCH1)
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus.
Gene Information
| Human | |
|---|---|
| Gene Name: | NOTCH1 |
| Uniprot: | P46531 |
| Entrez: | 4851 |
Family
| Belongs to: |
|---|
| NOTCH family |
Alternative Names
EC 2.1.2.11; EC 3.4.21.68; hN1; Notch (Drosophila) homolog 1 (translocation-associated); notch 1Notch homolog 1, translocation-associated (Drosophila); Notch homolog 1, translocation-associated; Notch1; Notch-1; TAN1; TAN1neurogenic locus notch homolog protein 1; Translocation-associated notch protein TAN-1
Molecular Weight
Mass (kDA):
272.505 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.3 |
| Sequence: | 9; NC_000009.12 (136494433..136546048, complement) |
Tissue Specificity
In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.; [Notch 1 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus. Nuclear location may require MEGF10.
Diseases
- Neoplasms
- Malignant Neoplasms
- Leukemia
- Precursor T-cell Lymphoblastic Leukemia-lymphoma
- Cell Transformation, Neoplastic
- Acute Lymphocytic Leukemia
- Carcinoma
- Lymphoma
- Nervousness
- Tumor Angiogenesis
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
Interacting Proteins
- ATM
- FBXW7
- HIF1A
- JAG1
- KDM1A
- LILRB2
- MAML1
- NFKB1
- PIN1
- RBPJ
Pathways
- Notch Signaling Pathway
- Cell Proliferation
- Cell Differentiation
- Pathogenesis
- Cell Cycle
- Cell Growth
- Neurogenesis
- Cell Development
- Angiogenesis
- Localization
- Cell Fate Determination
- Cell Death
- Regeneration
PTMs
- Cleavage
- Phosphorylation
- Methylation
- Ubiquitination
- Glycosylation
- Acetylation
- Hydroxylation
- Reduction
Research Areas
- Cancer Stem Cells
- Golgi Apparatus Markers
- Growth and Development
- Neuronal Cell Markers
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NOTCH1
bosterbio.com/bosterbio-gene-info-cards/NOTCH1
References
PMID: 1831692 by Ellisen L.W., et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.
PMID: 17573339 by Coleman M.L., et al. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
2 Publications of Boster NOTCH1 Antibodies & ELISA Kits
- PubMed ID: 28713967, Involvement of Notch2 in all%u2011trans retinoic acid%u2011induced inhibition of...
- PubMed ID: 25536154, Mi L, Chen Y, Zheng X, Li Y, Zhang Q, Mo D, Yang G. J Cell Biochem. 2015 Jul;116...
*More publications can be found for each product on its corresponding product page