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PACS1 Antibodies
AND PACS1 ELISA kits, PACS1 Proteins
Many biological assays use antibodies to detect PACS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PACS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PACS1 antibodies...
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PACS1 Overview
Facts about Phosphofurin acidic cluster sorting protein 1.
Phosphofurin acidic cluster sorting protein 1 (PACS1)
Coat protein that's involved in the localization of trans-Golgi network (TGN) membrane proteins which contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits.
Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PACS1 |
| Uniprot: | Q6VY07 |
| Entrez: | 55690 |
Family
| Belongs to: |
|---|
| PACS family |
Alternative Names
cytosolic sorting protein PACS-1; FLJ10209; KIAA1175; PACS-1; phosphofurin acidic cluster sorting protein 1
Molecular Weight
Mass (kDA):
104.898 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.1-q13.2 |
| Sequence: | 11; NC_000011.10 (66070272..66244744) |
Subcellular Localizations
Golgi apparatus, trans-Golgi network. Localizes in the perinuclear region, probably the TGN.
Diseases
- Hiv Infections
- Immunologic Deficiency Syndromes
- Malignant Neoplasms
- Acquired Immunodeficiency Syndrome
- Cytomegalovirus Infections
- Kidney Diseases
- Melanoma
- Neurodegenerative Disorders
- Uterine Cervical Neoplasm
- Dementia
- Anosmia
- Ataxia
Interacting Proteins
- CSNK2B
- GGA3
- IGF2R
Pathways
- Localization
- Transport
- Secretory Pathway
- Endocytosis
- Protein Transport
- Pathogenesis
- Clathrin-mediated Endocytosis
- Cell Death
PTMs
- Phosphorylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PACS1
bosterbio.com/bosterbio-gene-info-cards/PACS1
References
PMID: 11331585 by Crump C.M., et al. PACS-1 binding to adaptors is required for acidic cluster motif- mediated protein traffic.
PMID: 10707087 by Piguet V., et al. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes.