PHOX2A Antibodies

AND PHOX2A ELISA kits, PHOX2A Proteins

Many biological assays use antibodies to detect PHOX2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHOX2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHOX2A antibodies...

We validate the specificity of these antibodies to PHOX2A by testing them on tissues known to express PHOX2A positively and negatively. Browse below to find the PHOX2A antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for PHOX2A? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the PHOX2A IHC Guide

PHOX2A Infographic by Boster Bio

All PHOX2A Products

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Anti-PHOX2A Antibody

Western blot analysis of PHOX2A in rat brain tissue lysate with PHOX2A antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide

Immunohistochemistry of PHOX2A in human brain tissue with PHOX2A antibody at 2

Immunofluorescence of PHOX2A in human brain tissue with PHOX2A antibody at 20 μg/mL

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$481
Cat # A05780
0.1 mg

PHOX2A (NM_005169) Human Over-expression Lysate

Human

$628
Cat # LS000401
20 µg, 100 µg

PHOX2A Overview

Facts about Paired mesoderm homeobox protein 2A.

PHOX2A 3D structure. Source: alphafold

Paired mesoderm homeobox protein 2A (PHOX2A)

May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor.

Could maintain the noradrenergic phenotype. .

Gene Information

Human
Gene Name:	PHOX2A
Uniprot:	O14813
Entrez:	401

Family

Belongs to:

paired homeobox family

Alternative Names

aristaless (Drosophila) homeobox, aristaless homeobox (Drosophila), fibrosis ofextraocular muscles, congenital, 2, autosomal recessive; aristaless homeobox homolog; Aristaless homeobox protein homolog; arix homeodomain protein; ARIX1 homeodomain protein; ARIXNCAM2; CFEOM2MGC52227; paired mesoderm homeobox protein 2A; paired-like homeobox 2apaired-like (aristaless) homeobox 2a; PMX2AFEOM2

Molecular Weight

Mass (kDA):
29.653 kDA

Genomic Context


Human

Location:	11q13.4
Sequence:	11; NC_000011.10 (72239077..72244176, complement)

Subcellular Localizations

Nucleus.

Diseases

Nervousness
Crest Syndrome
Neuroblastoma
Strabismus
Fibrosis
Ophthalmoplegia
Blepharoptosis
Exotropia
Disease Of Adrenal Medulla
Ocular Motility Disorders
Congenital Central Hypoventilation
Hypoventilation

Neoplasms
Congenital Abnormality
Hypoxia
Misalignment
Downward Ocular Deviation
Embryonic Mosaic
Eye Diseases, Hereditary

Pathways

Neurogenesis
Neuron Development
Neuron Differentiation
Pathogenesis
Innervation
System Development
Cell Differentiation
Cell Development
Cell Death
Nervous System Development
Aging
Reflex
Autonomic Nervous System Development

Cell Cycle
Localization
Dna Amplification
Delamination
Secretion
Transport
Cell Fate Determination

PTMs

Phosphorylation

Dephosphorylation

Acetylation

Research Areas

Growth and Development
Neuronal Cell Markers
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHOX2A

References

PMID: 8661014 by Johnson K.R., et al. Mapping of the ARIX homeodomain gene to mouse chromosome 7 and human chromosome 11q13.

PMID: 11600883 by Nakano M., et al. Homozygous mutations in ARIX(PHOX2A) result in congenital fibrosis of the extraocular muscles type 2.