PPBP Infographic
Platelet basic protein Info At a glance, species: Human
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Platelet basic protein (PPBP)
LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. Additionally, it stimulates the formation and secretion of plasminogen activator by human synovial cells.
NAP-2 is a ligand for both CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and many potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules.
Gene Information
Human | |
---|---|
Gene Name: | PPBP |
Uniprot: | P02775 |
Entrez: | 5473 |

Family
Belongs to: |
---|
intercrine alpha (chemokine CxC) family |

Alternative Names
Beta-TG; connective tissue-activating peptide III; CTAP III; CTAP3CTAP-III; CTAPIII; CXC chemokine ligand 7; C-X-C motif chemokine 7; CXCL7; CXCL7b-TG1; LA-PF4; LDGFTC1; Leukocyte-derived growth factor; low-affinity platelet factor IV; Macrophage-derived growth factor; MDGFTC2; NAP2; NAP-2; NAP-2-L1; neutrophil-activating peptide 2; neutrophil-activating peptide-2; PBPTHBGB; platelet basic protein; PPBP; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); SCAR10; SCYB7beta-thromboglobulin; small inducible cytokine B7; small inducible cytokine subfamily B, member 7; Small-inducible c
Molecular Weight
Mass (kDA):
13.894 kDA

Genomic Context
Human | |
---|---|
Location: | 4q13.3 |
Sequence: | 4; NC_000004.12 (73986439..73988190, complement) |
Subcellular Localizations
Secreted.

Diseases
- Inflammation
- Endocarditis
- Melanoma
- Infective Disorder
- Bacteremia
- Infarction
- Staphylococcal Infections
- Ischemia
- Bacterial Endocarditis
- Arterial Occlusion
- Occlusion, Middle Cerebral Artery
- Cerebral Artery Occlusion

Interacting Proteins
- CCL5
- CXCL9

Pathways
- Chemotaxis
- Pathogenesis
- Neuroprotection
- Secretion
- Neutrophil Chemotaxis
- Platelet Activation
- Neutrophil Activation
- Cell Activation
- Inflammatory Response
- Neutrophil Degranulation
- Cell Death
- Exocytosis
- Proteolysis

PTMs
- Cleavage
- Phosphorylation
- Formylation

bosterbio.com/bosterbio-gene-info-cards/PPBP
References
PMID: 2713489 by Wenger R.H., et al. Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library.
PMID: 1826003 by Majumdar S., et al. Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4.