PPBP Infographic

Platelet basic protein Info At a glance, species: Human

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Platelet basic protein (PPBP)

LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. Additionally, it stimulates the formation and secretion of plasminogen activator by human synovial cells.

NAP-2 is a ligand for both CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and many potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules.

Gene Information

Human
Gene Name:	PPBP
Uniprot:	P02775
Entrez:	5473

Family

Belongs to:

intercrine alpha (chemokine CxC) family

Alternative Names

Beta-TG; connective tissue-activating peptide III; CTAP III; CTAP3CTAP-III; CTAPIII; CXC chemokine ligand 7; C-X-C motif chemokine 7; CXCL7; CXCL7b-TG1; LA-PF4; LDGFTC1; Leukocyte-derived growth factor; low-affinity platelet factor IV; Macrophage-derived growth factor; MDGFTC2; NAP2; NAP-2; NAP-2-L1; neutrophil-activating peptide 2; neutrophil-activating peptide-2; PBPTHBGB; platelet basic protein; PPBP; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); SCAR10; SCYB7beta-thromboglobulin; small inducible cytokine B7; small inducible cytokine subfamily B, member 7; Small-inducible c

Molecular Weight

Mass (kDA):
13.894 kDA

Genomic Context


Human

Location:	4q13.3
Sequence:	4; NC_000004.12 (73986439..73988190, complement)

Subcellular Localizations

Secreted.

Diseases

Inflammation
Endocarditis
Melanoma
Infective Disorder
Bacteremia
Infarction
Staphylococcal Infections
Ischemia
Bacterial Endocarditis
Arterial Occlusion
Occlusion, Middle Cerebral Artery
Cerebral Artery Occlusion

Infective Endocarditis
Brain Ischemia
Pertussis
Malignant Neoplasms
Inflammatory Response
Tissue Adhesions
Cerebrovascular Accident

Interacting Proteins

CCL5
CXCL9

Pathways

Chemotaxis
Pathogenesis
Neuroprotection
Secretion
Neutrophil Chemotaxis
Platelet Activation
Neutrophil Activation
Cell Activation
Inflammatory Response
Neutrophil Degranulation
Cell Death
Exocytosis
Proteolysis

Localization
Angiogenesis
Cell Adhesion
Basophil Activation
Virulence
Wound Healing
Acute Inflammatory Response

PTMs

Cleavage
Phosphorylation
Formylation

Glycosylation
Dephosphorylation
Deglycosylation

Iodination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPBP

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References

PMID: 2713489 by Wenger R.H., et al. Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library.

PMID: 1826003 by Majumdar S., et al. Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4.