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- Table of Contents
Facts about Peroxiredoxin-6.
Also has phospholipase activity, and may therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These actions are determined by binding to phospholipids at acidic pH and to oxidized phospholipds in cytosolic pH.
Human | |
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Gene Name: | PRDX6 |
Uniprot: | P30041 |
Entrez: | 9588 |
Belongs to: |
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peroxiredoxin family |
1-Cys; 24 kDa protein; Acidic calcium-independent phospholipase A2; aiPLA2; aiPLA21-Cys PRX; Antioxidant protein 2; AOP2; AOP2Non-selenium glutathione peroxidase; EC 1.11.1.15; EC 1.11.1.7; EC 3.1.1.-; KIAA0106Red blood cells page spot 12; Liver 2D page spot 40; MGC46173; NSGPx; NSGPx1-Cys peroxiredoxin; p29; Peroxiredoxin 6; peroxiredoxin-6; PRDX6; PRX
Mass (kDA):
25.035 kDA
Human | |
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Location: | 1q25.1 |
Sequence: | 1; NC_000001.11 (173477335..173488815) |
Cytoplasm. Lysosome. Also found in lung secretory organelles (lamellar bodies).
This Boster Bio: Best Uses Of The Peroxiredoxin 6 Marker is a highly purified, recombinant protein expressed from E. coli. Its His-Tag is suitable for measuring enzyme activity and SDS-PAGE. The protein can be stored at -20 to +8degC for one week. It should be stored at -80degC for longer storage. It is recommended that you avoid repeated freeze-thaw cycles. You can also earn product credits when sharing your findings with Boster Bio. Product credits are given to scientists worldwide for sharing results.
A new study has discovered that Boster Bio's Anti-Peroxiredxin 6 marker identifies the stemness of cancer cells. The results of this study were published in the journal Anal Quant Cytol Histol. The study found that this gene is essential for the stemness of liver cancer cells. In addition, it was found to regulate the survival of A549 lung cancer cells and their resistance to the anticancer drug gefitinib.
The role of peroxiredoxin 6 is well-established in the development of mice. It is also required for proper NADPH oxidase activity and phospholipase A(2) activity. The anti-Peroxiredoxin 6 marker has shown promising results in clinical trials. This marker also detects oxidative stress and other biomarkers of aging.
The anti-Peroxiredoxin 6 antibody from Boster Bio is a part of the Picoband(tm) catalog. It is tested in IHC-P and ICC. It binds to human, mouse, and rat tissue samples. The anti-Peroxiredoxin 6 marker provides a validated, sensitive, and specific test results for both positive and negative samples.
Peroxiredoxins are a superfamily of proteins that function as antioxidants and exhibit peroxidase activity in TRx-dependent fashion. PRxVI contains one conserved cysteine, while PRxV and other members of the family have additional cysteines. PRxVI was isolated using a baculovirus system and purified by a two-step procedure. Purified PRxVI exhibited a low glutathione-dependent peroxidase activity and no TRx-dependent activity. The recombinant protein was expressed most abundantly in the lung, liver, kidney, heart, and lung.
PMID: 8999971 by Kim T.-S., et al. Identification of a human cDNA clone for lysosomal type Ca2+- independent phospholipase A2 and properties of the expressed protein.
PMID: 9050990 by Frank S., et al. The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene.