Many biological assays use antibodies to detect Ptcra, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ptcra in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ptcra antibodies...
We validate the specificity of these antibodies to Ptcra by testing them on tissues known to express Ptcra positively and negatively. Browse below to find the Ptcra antibody that suites your experiment. We have 25 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) modulates early T-cell development. Isoform 1 acts to retain most TCRB intracellularly, while isoform 2 permits higher levels of cell surface TCRB expression and facilitates signaling from the CD3-TCRB complex.
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Gene Information
Mouse
Gene Name:
Ptcra
Uniprot:
P0C6B2
Entrez:
19208
Family
Belongs to:
No superfamily
Alternative Names
Pre T-cell antigen receptor alpha
Molecular Weight
Mass (kDA): 21.491 kDA
Genomic Context
Mouse
Location:
17|17 C
Sequence:
17;
Tissue Specificity
Isoform 1 is expressed at higher levels than isoform 2 in the thymus while only isoform 2 is expressed in polyclonal beta-only cells. Isoform 1 shows a predominant expression in immature thymocytes.
PTMs
Disulfide bond
Glycoprotein
For details, visit: bosterbio.com/bosterbio-gene-info-cards/Ptcra
References
PMID: 7973703 by Saint-Ruf C., et al. Analysis and expression of a cloned pre-T cell receptor gene.
PMID: 7672822 by Fehling H.J., et al. Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene.