Pre T-cell antigen receptor alpha (Ptcra)

The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) modulates early T-cell development. Isoform 1 acts to retain most TCRB intracellularly, while isoform 2 permits higher levels of cell surface TCRB expression and facilitates signaling from the CD3-TCRB complex.

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