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- Table of Contents
Pleiotrophin Antibodies
AND PTN ELISA kits, Pleiotrophin Proteins
Many biological assays use antibodies to detect Pleiotrophin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pleiotrophin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pleiotrophin antibodies...
Designing a Western blot for Pleiotrophin? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PTN Western Blot GuideDesigning an IHC experiment for Pleiotrophin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PTN IHC GuidePTN Infographic by Boster Bio
All PTN Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01368-2
100 µg/vial
Cat # A01368-2
100 µg/vial
Human, Mouse, Rat
IHC, WB
$370
Cat # M01368
100 µl/vial
Cat # M01368
100 µl/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC1957
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1957
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1956
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1956
1 kit, containing two 96-well plates and all necessary reagents
PTN Overview
Facts about Pleiotrophin.
Pleiotrophin (PTN)
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720).
Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).
Gene Information
| Human | |
|---|---|
| Gene Name: | PTN |
| Uniprot: | P21246 |
| Entrez: | 5764 |
Family
| Belongs to: |
|---|
| pleiotrophin family |
Alternative Names
HARP; HBBM; HB-GAM; HBGF8; HBNF; HBNF1; HBNF-1; Heparin-binding brain mitogen; HNGF-8; NEGF1HBGF-8; neurite growth-promoting factor 1; neurite growth-promoting factor1); OSF-1; Osteoblast-specific factor 1; Pleiotrophin; PTN
Molecular Weight
Mass (kDA):
18.942 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q33 |
| Sequence: | 7; NC_000007.14 (137227341..137343733, complement) |
Tissue Specificity
Osteoblast and brain.
Subcellular Localizations
Secreted.
Diseases
- Neoplasms
- Malignant Neoplasms
- Tumor Angiogenesis
- Malignant Paraganglionic Neoplasm
- Nervousness
- Pathologic Neovascularization
- Neoplasm Metastasis
- Carcinoma
- Lymphoma
- Glioblastoma
- Anaplastic Lymphoma
- Pain
Pathways
- Angiogenesis
- Regeneration
- Cell Proliferation
- Localization
- Cell Growth
- Cell Migration
- Pathogenesis
- Cell Adhesion
- Reflex
- Osteoblast Differentiation
- Neurogenesis
- Locomotion
- Cell Cycle
PTMs
- Phosphorylation
- Nitration
- Cleavage
- Methylation
- Dephosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTN
bosterbio.com/bosterbio-gene-info-cards/PTN
References
PMID: 1701634 by Tezuka K.I., et al. Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues.
PMID: 2270483 by Li Y.-S., et al. Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity.
1 Publications of Boster Pleiotrophin Antibodies & ELISA Kits
- PubMed ID: 28678802, miR-182 aids in receptive endometrium development in dairy goats by down-regulat...
*More publications can be found for each product on its corresponding product page