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- Table of Contents
PON1 Antibodies
AND PON1 ELISA kits, PON1 Proteins
Many biological assays use antibodies to detect PON1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PON1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PON1 antibodies...
Designing a Western blot for PON1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PON1 Western Blot GuidePON1 Infographic by Boster Bio
All PON1 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$499
Cat # EK1621
96 wells/kit, with removable strips.
Cat # EK1621
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # EK1141
96 wells/kit, with removable strips.
Cat # EK1141
96 wells/kit, with removable strips.
Mouse
ELISA
$500
Cat # EZ1621
For 5 plates, 96 wells each
Cat # EZ1621
For 5 plates, 96 wells each
Mouse, Rat
IHC, WB, ELISA (Cap)
$370
Cat # M00516-1
100 μg/vial
Cat # M00516-1
100 μg/vial
Mouse, Rat
IHC, WB, ELISA (Cap)
$370
Cat # M00516
100 μg/vial
Cat # M00516
100 μg/vial
PON1 Overview
Facts about Serum paraoxonase/arylesterase 1.
Serum paraoxonase/arylesterase 1 (PON1)
Hydrolyzes the toxic metabolites of an assortment of organophosphorus insecticides. Capable of hydrolyzing a wide spectrum of organophosphate substrates and lactones, and a range of aromatic carboxylic acid esters.
Mediates an enzymatic defense of low density lipoproteins against oxidative modification and the consequent series of events resulting in atheroma formation. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PON1 |
| Uniprot: | P27169 |
| Entrez: | 5444 |
Family
| Belongs to: |
|---|
| paraoxonase family |
Alternative Names
A-esterase 1; Aromatic esterase 1; arylesterase B-type; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; ESA; ESAesterase A; K-45; MVCD5; paraoxonase 1; PON 1; PON1; PONparaoxonase B-type; serum aryldiakylphosphatase; Serum aryldialkylphosphatase 1; serum paraoxonase/arylesterase 1
Molecular Weight
Mass (kDA):
39.731 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q21.3 |
| Sequence: | 7; NC_000007.14 (95297676..95324532, complement) |
Tissue Specificity
Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
Subcellular Localizations
Secreted, extracellular space.
Diseases
- Atherosclerosis
- Cardiovascular Diseases
- Diabetes Mellitus
- Coronary Heart Disease
- Coronary Artery Disease
- Heart Diseases
- Inflammation
- Diabetes Mellitus, Non-insulin-dependent
- Arteriosclerosis
- Infarction
- Hypertensive Disease
- Myocardial Infarction
Pathways
- Pathogenesis
- Aging
- Lipoprotein Oxidation
- Cholesterol Efflux
- Transport
- Lipid Oxidation
- Secretion
- Cholesterol Transport
- Inflammatory Response
- Reverse Cholesterol Transport
- Excretion
- Localization
- Quorum Sensing
PTMs
- Oxidation
- Phosphorylation
- Cleavage
- Glycosylation
- Reduction
- Cysteinylation
Research Areas
- Alzheimers Research
- Cancer
- Lipid and Metabolism
- Neurodegeneration
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PON1
bosterbio.com/bosterbio-gene-info-cards/PON1
References
PMID: 1657140 by Hassett C., et al. Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence.
PMID: 7916578 by Adkins S., et al. Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes.
4 Publications of Boster PON1 Antibodies & ELISA Kits
- PubMed ID: 10.1111/fcp.12661, Effect of dapagliflozin and/or L‐arginine on solid tumor model in mice: The in...
- PubMed ID: 10.1002/mnfr.201800404, Long‐Term Supplementation of Black Elderberries Promotes Hyperlipidemia, but R...
- PubMed ID: , Pro-Oxidative and Proinflammatory Effects After Traveling From Los Angeles to Be...
- PubMed ID: -, Kabel,A.M.,Arab,H.H. and Abd Elmaaboud,M.A. (2021),Effect of dapagliflozin and/o...
*More publications can be found for each product on its corresponding product page