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- Table of Contents
RNF2 Antibodies
AND RNF2 ELISA kits, RNF2 Proteins
Many biological assays use antibodies to detect RNF2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNF2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNF2 antibodies...
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RNF2 Infographic by Boster Bio
All RNF2 Products
Product
Figures
Specificity
Applications
Price
Anti-RING1B RNF2 Antibody
6 Q&As
Human, Mouse, Chinese hamster
ELISA, IF, WB
$641
Cat # A01209-1
100ug
Cat # A01209-1
100ug
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01209
100 μl
Cat # M01209
100 μl
RNF2 Overview
Facts about E3 ubiquitin-protein ligase RING2.
E3 ubiquitin-protein ligase RING2 (RNF2)
H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity).
Essential element of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class necessary to keep the transcriptionally repressive state of several genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts through chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332).
Gene Information
| Human | |
|---|---|
| Gene Name: | RNF2 |
| Uniprot: | Q99496 |
| Entrez: | 6045 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BAP-1; BAP1RING finger protein 1B; DING; DINGRING finger protein BAP-1; EC 6.3.2; HIPI3; HIPI3RING1BE3 ubiquitin-protein ligase RING2; Huntingtin-interacting protein 2-interacting protein 3; Protein DinG; ring finger protein 2HIP2-interacting protein 3; RING1B; RING2; RING2EC 6.3.2.-; RNF2
Molecular Weight
Mass (kDA):
37.655 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q25.3 |
| Sequence: | 1; NC_000001.11 (185045430..185102603) |
Subcellular Localizations
Nucleus. Chromosome. Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells.
Diseases
- Malignant Neoplasms
- Neoplasms
- Lymphoma
- Cell Transformation, Neoplastic
- Atherosclerosis
- Hiv Infections
- Malignant Neoplasm Of Breast
- Cachexia
- Mammary Neoplasms
- Rheumatoid Arthritis
- Malignant Paraganglionic Neoplasm
- Atrophy
- Arthritis
Interacting Proteins
- ABCB1
- BMI1
- CBX4
- CBX6
- CBX7
- CBX8
- CSNK2A1
- CSNK2B
- HIST1H2AG
- KAT8
Pathways
- Gene Silencing
- Cell Cycle
- Cell Proliferation
- Localization
- Methylation
- Cell Differentiation
- Histone Ubiquitination
- Regulation Of Gene Expression
- Chromatin Remodeling
- Histone Deacetylation
- Dna Repair
- Dna Methylation
- Pathogenesis
PTMs
- Ubiquitination
- Methylation
- Phosphorylation
- Acetylation
- Deacetylation
Research Areas
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNF2
bosterbio.com/bosterbio-gene-info-cards/RNF2
References
PMID: 11513855 by Lee S.-J., et al. E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme.
PMID: 11865070 by Tuckfield A., et al. Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors.