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- Table of Contents
Transcription factor PU.1 Antibodies
AND SPI1 ELISA kits, Transcription factor PU.1 Proteins
Many biological assays use antibodies to detect Transcription factor PU.1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor PU.1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor PU.1 antibodies...
Designing a Western blot for Transcription factor PU.1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SPI1 Western Blot GuideSPI1 Infographic by Boster Bio
All SPI1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01116-1
100 μg/vial
Cat # A01116-1
100 μg/vial
Mouse
ELISA
$499
Cat # EK1711
96 wells/kit, with removable strips.
Cat # EK1711
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA
$480
Cat # EKC1684
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1684
1 kit, containing one 96-well plate and all necessary reagents
SPI1 Overview
Facts about Transcription factor PU.1.
Transcription factor PU.1 (SPI1)
Binds to the PU-box, a purine-rich DNA sequence (5'- GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells.
Also binds RNA and may modulate pre-mRNA splicing (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | SPI1 |
| Uniprot: | P17947 |
| Entrez: | 6688 |
Family
| Belongs to: |
|---|
| ETS family |
Alternative Names
hematopoietic transcription factor PU.1; OF; PU.1; SFPI1; SFPI131 kDa transforming protein; SPI-1 proto-oncogene; SPI1; Spi-1; SPI-A; spleen focus forming virus (SFFV) proviral integration oncogene spi1,31 kDa-transforming protein; transcription factor PU.1
Molecular Weight
Mass (kDA):
31.083 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p11.2 |
| Sequence: | 11; NC_000011.10 (47354859..47395640, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Salmonella Infections
- Cell Invasion
- Leukemia
- Salmonella Infections, Animal
- Diarrhea
- Malignant Neoplasms
- Myeloid Leukemia
- Inflammation
- Neoplasms
- Leukemia, Myelocytic, Acute
- Infective Disorder
- Tissue Adhesions
- Disease Caused By Shigella Flexneri
Interacting Proteins
- GATA2
- HOXA10
- PRKDC
Pathways
- Secretion
- Virulence
- Pathogenesis
- Transport
- Phagocytosis
- Cell Cycle
- Mitosis
- Immune Response
- Protein Secretion
- Dna Replication
- Cell Death
- Oncogenesis
- Inflorescence Development
PTMs
- Phosphorylation
- Acetylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPI1
bosterbio.com/bosterbio-gene-info-cards/SPI1
References
PMID: 1693183 by Ray D., et al. The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors.
PMID: 10196196 by Rao S., et al. SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.