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TNFSF11 Antibodies
AND TNFSF11 ELISA kits, TNFSF11 Proteins
Many biological assays use antibodies to detect TNFSF11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TNFSF11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TNFSF11 antibodies...
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TNFSF11 Infographic by Boster Bio
All TNFSF11 Products
Product
Figures
Specificity
Applications
Price
Anti-RANKL/TNFSF11 Antibody Picoband®
2 Citations 1 Q&As
Mouse, Rat
ELISA, WB
$370
Cat # PB10015
100 μg/vial
Cat # PB10015
100 μg/vial
Rat TNFSF11/RANKL ELISA Kit PicoKine®
6 Citations 10 Q&As
Rat
ELISA
$499
Cat # EK1559
96 wells/kit, with removable strips.
Cat # EK1559
96 wells/kit, with removable strips.
Human TNFSF11/RANKL ELISA Kit PicoKine®
26 Citations 33 Q&As
Human
ELISA
$399
Cat # EK0842
96 wells/kit, with removable strips.
Cat # EK0842
96 wells/kit, with removable strips.
Mouse TNFSF11/RANKL ELISA Kit PicoKine®
28 Citations 8 Q&As
Mouse
ELISA
$499
Cat # EK0843
96 wells/kit, with removable strips.
Cat # EK0843
96 wells/kit, with removable strips.
Anti-sRANK Ligand TNFSF11 Antibody
1 Citations
Human, Mouse, Rat
ELISA, IHC-P, WB
$449
Cat # A00363-1
0.1 mg
Cat # A00363-1
0.1 mg
Human
ELISA
$499
Cat # FEK0842
96 wells/kit, with removable strips.
Cat # FEK0842
96 wells/kit, with removable strips.
Human
SDS-PAGE, Bioactivity
$294
Cat # PROTO14788-5
starting from 10ug
Cat # PROTO14788-5
starting from 10ug
TNFSF11 Overview
Facts about Tumor necrosis factor ligand superfamily member 11.
Tumor necrosis factor ligand superfamily member 11 (TNFSF11)
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK.
Osteoclast differentiation and activation element.Augments the capacity of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and might play a role in the regulation of this T-cell-dependent immune response.
Gene Information
| Human | |
|---|---|
| Gene Name: | TNFSF11 |
| Uniprot: | O14788 |
| Entrez: | 8600 |
Family
| Belongs to: |
|---|
| tumor necrosis factor family |
Alternative Names
CD254 antigen; CD254; ODF; OPGL; OPGLOPTB2; Osteoclast differentiation factor; Osteoprotegerin ligand; RANK L; RANKL; RANKLreceptor activator of nuclear factor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand; sOdf; TNF-related activation-induced cytokine; TNFSF11; TRANCE; TRANCEODFhRANKL2; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11
Molecular Weight
Mass (kDA):
35.478 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q14.11 |
| Sequence: | 13; NC_000013.11 (42562736..42608013) |
Tissue Specificity
Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type II membrane protein.; [Isoform 3]: Cell membrane; Single-pass type II membrane protein.; [Isoform 2]: Cytoplasm.; [Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted.
Diseases
- Osteoporosis
- Osteopenia
- Arthritis
- Bone Diseases
- Rheumatoid Arthritis
- Malignant Neoplasms
- Neoplasms
- Osteolysis
- Inflammation
- Bone Neoplasms
- Neoplasm Metastasis
- Multiple Myeloma
- Fracture
Interacting Proteins
- TNFAIP6
- TNFRSF11A
- TNFRSF11B
Pathways
- Bone Resorption
- Osteoclast Differentiation
- Bone Remodeling
- Pathogenesis
- Secretion
- Osteoclast Development
- Osteoblast Differentiation
- Cell Proliferation
- Localization
- Cell Growth
- Immune Response
- Cell Differentiation
- Cytokine Production
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Acetylation
- Methylation
- Dephosphorylation
- Prenylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNFSF11
bosterbio.com/bosterbio-gene-info-cards/TNFSF11
References
PMID: 9367155 by Anderson D.M., et al. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
PMID: 9568710 by Lacey D.L., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
53 Publications of Boster TNFSF11 Antibodies & ELISA Kits
- PubMed ID: 10.7150/ijms.27470, Nitrogen Containing Bisphosphonates Impair the Release of Bone Homeostasis Media...
- PubMed ID: 10.3892/mmr.2019.10688, LAPTM5 is transactivated by RUNX2 and involved in RANKL trafficking in osteoblas...
- PubMed ID: 10.3727/096504016X14768398678750, Validity of Osteoprotegerin and Receptor Activator of NF-κB Ligand for the Dete...
- PubMed ID: 10.3390/molecules24020271, Cajanolactone A from Cajanus cajan Promoted Osteoblast Differentiation in Human ...
- PubMed ID: 10.3389/fphar.2018.01286, Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo
- PubMed ID: 10.3389/fimmu.2018.00831, Inflammatory Response of Human Peripheral Blood Mononuclear Cells and Osteoblast...
- PubMed ID: 10.3389/fcell.2021.640867, Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis a...
- PubMed ID: 10.2147/DDDT.S328238, Oroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Form...
- PubMed ID: 10.18632/oncotarget.12763, An in vitro 3D bone metastasis model by using a human bone tissue culture and hu...
- PubMed ID: 10.1186/s13052-019-0748-1, OPG / RANK / RANKL signaling axis in patients with type I diabetes: Associations...
- PubMed ID: 10.1159/000323986, Panax notoginseng Saponins Potentiate Osteogenesis of Bone Marrow Stromal Cells ...
- PubMed ID: 10.1155/2020/6953421, RANKL Is Involved in Runx2-Triggered Hepatic Infiltration of Macrophages in Mice...
- PubMed ID: 10.1096/fj.201600825RRR, REV-ERB agonism suppresses osteoclastogenesis and prevents ovariectomy-induced b...
- PubMed ID: 10.1088/1758-5090/abefea, Engineering the early bone metastatic niche through human vascularized immuno bo...
- PubMed ID: 10.1080/10717544.2021.2009937, Novel optimized drug delivery systems for enhancing spinal cord injury repair in...
- PubMed ID: 10.1038/srep13575, Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Lo...
- PubMed ID: 10.1038/s41598-021-03484-5, Bioengineering the ameloblastoma tumour to study its effect on bone nodule forma...
- PubMed ID: 10.1038/s41598-019-50336-4, Bone loss caused by dopaminergic degeneration and levodopa treatment in Parkinso...
- PubMed ID: 10.1038/s41419-020-2314-6, NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthrit...
- PubMed ID: 10.1038/leu.2015.259, Osteolytic lesions, cytogenetic features and bone marrow levels of cytokines and...
- PubMed ID: 10.1021/acsbiomaterials.8b01468, Microfiber-Reinforced Composite Hydrogels Loaded with Rat Adipose-Derived Stem C...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page