Many biological assays use antibodies to detect TRAC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRAC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRAC antibodies...
We validate the specificity of these antibodies to TRAC by testing them on tissues known to express TRAC positively and negatively. Browse below to find the TRAC antibody that suites your experiment. We have 44 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.
Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.
Gene Information
Human
Gene Name:
TRAC
Uniprot:
P01848
Entrez:
28755
Family
Belongs to:
No superfamily
Alternative Names
T cell receptor alpha constant
Molecular Weight
Mass (kDA): 15.717 kDA
Genomic Context
Human
Location:
14q11.2
Sequence:
14; NC_000014.9 (22547506..22552132)
Subcellular Localizations
Cell membrane.
PTMs
Disulfide bond
Glycoprotein
For details, visit: bosterbio.com/bosterbio-gene-info-cards/TRAC
References
PMID: 3875483 by Rabbitts T.H., et al. The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia.
PMID: 3873654 by Yanagi Y., et al. Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line.
10 Publications of Boster TRAC Antibodies & ELISA Kits
PubMed ID: 10.1371/journal.pone.0101026, Elevated Urinary Levels of Cystatin C and Neutrophil Gelatinase-Associated Lipoc...
PubMed ID: 10.1186/s13054-020-02887-6, The value of plasma pro-enkephalin and adrenomedullin for the prediction of seps...
PubMed ID: 10.1016/j.ijcard.2015.04.242, Prognostic impact of established and novel renal function biomarkers in myocardi...
PubMed ID: 10.1002/jum.15225, Effects of Therapeutic Ultrasound Applied to the Lumbar Region on Renal Function