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- Table of Contents
TRAF4 Antibodies
AND TRAF4 ELISA kits, TRAF4 Proteins
Many biological assays use antibodies to detect TRAF4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRAF4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRAF4 antibodies...
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TRAF4 Infographic by Boster Bio
All TRAF4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
Flow Cytometry, IF, ICC, WB
$370
Cat # M03069
100 μl
Cat # M03069
100 μl
TRAF4 Overview
Facts about TNF receptor-associated factor 4.
TNF receptor-associated factor 4 (TRAF4)
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis.
Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | TRAF4 |
| Uniprot: | Q9BUZ4 |
| Entrez: | 9618 |
Family
| Belongs to: |
|---|
| TNF receptor-associated factor family |
Alternative Names
CART1; CART1RING finger protein 83; Cysteine-rich domain associated with RING and Traf domains protein 1; Metastatic lymph node gene 62 protein; MLN 62; MLN62; MLN62cysteine-rich domain associated with ring and TRAF domain; RNF83malignant 62; TNF receptor-associated factor 4; TRAF4; TRAF-4; tumor necrosis receptor-associated factor 4A
Molecular Weight
Mass (kDA):
53.543 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q11.2 |
| Sequence: | 17; NC_000017.11 (28744004..28750956) |
Tissue Specificity
Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus.
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Diseases
- Carcinoma
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Nervousness
- Noninfiltrating Intraductal Carcinoma
- Ductal Carcinoma
- Tissue Adhesions
- Carcinoma In Situ
- Lymphoma
- Congenital Abnormality
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- ALKBH4
- BAHD1
- BANP
- BYSL
- DTX3
- FAM214B
- GOLGA2
- GORASP2
- HGS
- ISYNA1
Pathways
- Localization
- Cell Death
- Cell Migration
- Cell Cycle
- Cell Proliferation
- Ventral Furrow Formation
- Intracellular Signal Transduction
- Cell Adhesion
- Osteoclast Differentiation
- Neural Tube Closure
- Programmed Cell Death
- Immune Response
- Axon Regeneration
PTMs
- Phosphorylation
Research Areas
- Cancer
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAF4
bosterbio.com/bosterbio-gene-info-cards/TRAF4
References
PMID: 7490069 by Tomasetto C.L., et al. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.
PMID: 7592751 by Regnier C.H., et al. Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma.