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- Table of Contents
TRPV4 Antibodies
AND TRPV4 ELISA kits, TRPV4 Proteins
Many biological assays use antibodies to detect TRPV4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRPV4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRPV4 antibodies...
Designing a Western blot for TRPV4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TRPV4 Western Blot GuideDesigning an IHC experiment for TRPV4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TRPV4 IHC GuideTRPV4 Infographic by Boster Bio
All TRPV4 Products
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TRPV4 Overview
Facts about Transient receptor potential cation channel subfamily V member 4.
Transient receptor potential cation channel subfamily V member 4 (TRPV4)
Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574).
Increase of intracellular Ca(2+) potentiates currents. Channel activity appears to be controlled by a calmodulin-dependent mechanism using a negative feedback mechanism (PubMed:12724311, PubMed:18826956).
Gene Information
| Human | |
|---|---|
| Gene Name: | TRPV4 |
| Uniprot: | Q9HBA0 |
| Entrez: | 59341 |
Family
| Belongs to: |
|---|
| transient receptor (TC 1.A.4) family |
Alternative Names
CMT2Cosmosensitive transient receptor potential channel 4; HMSN2C; Osm-9-like TRP channel 4; OTRPC4SSQTL1; transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily V, member 4; Transient receptor potential protein 12; TRP12OSM9-like transient receptor potential channel 4; TrpV4; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; vanilloid receptor-related osmotically activated channel; Vanilloid receptor-related osmotically-activated channel; VRL2; VRL-2; VR-OAC; VROACSPSMA
Molecular Weight
Mass (kDA):
98.281 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.11 |
| Sequence: | 12; NC_000012.12 (109783087..109833398, complement) |
Tissue Specificity
Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level).
Subcellular Localizations
Apical cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Cell projection, cilium. Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum.; [Isoform 1]: Cell membrane.; [Isoform 5]: Cell membrane.; [Isoform 2]: Endoplasmic reticulum.; [Isoform 4]: Endoplasmic reticulum.; [Isoform 6]: Endoplasmic reticulum.
Diseases
- Pain
- Edema
- Inflammation
- Hyperalgesia
- Hypertensive Disease
- Nervousness
- Dysplasia
- Atrophy
- Muscular Atrophy
- Spinal Muscular Atrophy
- Hereditary Motor And Sensory Neuropathies
Interacting Proteins
- Aqp4
Pathways
- Localization
- Pathogenesis
- Hypersensitivity
- Sensitization
- Secretion
- Transport
- Vasodilation
- Reflex
- Micturition
- Cell Proliferation
- Muscle Contraction
- Membrane Depolarization
- Vasoconstriction
PTMs
- Phosphorylation
- Glycosylation
- Ubiquitination
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPV4
bosterbio.com/bosterbio-gene-info-cards/TRPV4
References
PMID: 11081638 by Liedtke W.B., et al. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor.
PMID: 11025659 by Strotmann R., et al. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity.