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- Table of Contents
TRPV5 Antibodies
AND TRPV5 ELISA kits, TRPV5 Proteins
Many biological assays use antibodies to detect TRPV5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRPV5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRPV5 antibodies...
Designing a Western blot for TRPV5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TRPV5 Western Blot GuideDesigning an IHC experiment for TRPV5? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TRPV5 IHC GuideTRPV5 Infographic by Boster Bio
All TRPV5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, IHC-F, ICC, WB
$370
Cat # A03218-1
100 μg/vial
Cat # A03218-1
100 μg/vial
Mouse
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A03220-2
100 μg/vial
Cat # A03220-2
100 μg/vial
TRPV5 Overview
Facts about Transient receptor potential cation channel subfamily V member 5.
Transient receptor potential cation channel subfamily V member 5 (TRPV5)
Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity).
The station is triggered by low internal calcium level and the present exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback law includes fast channel inactivation and slow current decay (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | TRPV5 |
| Uniprot: | Q9NQA5 |
| Entrez: | 56302 |
Family
| Belongs to: |
|---|
| transient receptor (TC 1.A.4) family |
Alternative Names
Calcium transport protein 2; calcium transporter 2; CAT2; ECaC; ECAC1; ECAC1CaT2; Epithelial calcium channel 1CAT2; Osm-9-like TRP channel 3; OTRPC3; transient receptor potential cation channel subfamily V member 5; transient receptor potential cation channel, subfamily V, member 5; TRPV5
Molecular Weight
Mass (kDA):
82.551 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q34 |
| Sequence: | 7; NC_000007.14 (142908101..142933746, complement) |
Tissue Specificity
Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.
Subcellular Localizations
Apical cell membrane; Multi-pass membrane protein. Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3 (PubMed:18768590).
Diseases
- Hypercalciuria
- Kidney Diseases
- Hypertensive Disease
- Osteoporosis
- Hypocalcemia
- Hypercalcemia
- Kidney Calculi
- Rickets
- Malignant Neoplasms
- Pain
- Neoplasms
Interacting Proteins
- CALB1
Pathways
- Transport
- Excretion
- Localization
- Pathogenesis
- Aging
- Intestinal Absorption
- Bone Resorption
- Secretion
- Ion Transport
- Glycosylation
- Endocytosis
- Cell Proliferation
- Muscle Contraction
PTMs
- Glycosylation
- Phosphorylation
- Cleavage
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPV5
bosterbio.com/bosterbio-gene-info-cards/TRPV5
References
PMID: 10945469 by Mueller D., et al. Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial calcium channel (ECAC1).
PMID: 11549322 by Peng J.-B., et al. Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.