Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Acts as decoy receptor for TNFSF11/RANKL and thus neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro.

Bone homeostasis appears to be based on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification.