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- Table of Contents
2 Citations 1 Q&As
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26 Citations 33 Q&As
28 Citations 8 Q&As
1 Citations
Facts about Tumor necrosis factor ligand superfamily member 11.
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK.
Osteoclast differentiation and activation element.Augments the capacity of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and might play a role in the regulation of this T-cell-dependent immune response.
Human | |
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Gene Name: | TNFSF11 |
Uniprot: | O14788 |
Entrez: | 8600 |
Belongs to: |
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tumor necrosis factor family |
CD254 antigen; CD254; ODF; OPGL; OPGLOPTB2; Osteoclast differentiation factor; Osteoprotegerin ligand; RANK L; RANKL; RANKLreceptor activator of nuclear factor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand; sOdf; TNF-related activation-induced cytokine; TNFSF11; TRANCE; TRANCEODFhRANKL2; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11
Mass (kDA):
35.478 kDA
Human | |
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Location: | 13q14.11 |
Sequence: | 13; NC_000013.11 (42562736..42608013) |
Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.
[Isoform 1]: Cell membrane; Single-pass type II membrane protein.; [Isoform 3]: Cell membrane; Single-pass type II membrane protein.; [Isoform 2]: Cytoplasm.; [Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted.
Boster Bio has created a Mouse TNFSF11 PicoKine ELISA Kit and Anti-RANKL/TNFSF11 Antibody Picoband. To ensure high specificity and affinity, each product is tested using positive and negative samples. Boster also offers the first reviewer credits for the product. This program is open to researchers from all over the globe.
The anti-RANKL/TNFSF11 antibody from Boster Bio is a flexible highly specific and efficient tool for use in western blot (WB) immunoassays. The antibody recognizes the antigens of human mice, rats, and mouse. It has been confirmed by various methods, including WB, IHC, and Immunofluorescence.
The Boster Bio Mouse RANKL PicoKine(tm), ELISa Kit measures the levels of Mouse TNFSF11/RANKL in supernatant from cell culture, serum and cells lysates that contain EDTA. The ELISA kit is compatible with all the most well-known cell culture mediums and is suitable for use in a wide range of applications.
This Mouse TNFSF11/RANKL ELISA kit was designed to measure the levels of RANKL in plasma and serum from mice. The serum and cells of mice were homogenized with RIPA buffer. The RNA was isolated by using an RNeasy Mini Kit by QIAGEN. RNA was then isolated and subjected RT-PCR StepOnePlus (Thermo Fisher) and SYBR Green Plus (Toyobo). The mRNA levels were then normalized by using Gapdh.
To determine the presence of TNFSF11/RANKL cytokines in blood samples, the Boster Bio Mouse TNFSF11/RRANKL PicoKine(t) ELISA kit can accurately detect these two cytokines. This ELISA kit will help assess the risk of bone cancer in patients. The ELISA kit can be purchased in sandwich or titration formats.
Boster Bio Mouse PicoKine(t), an ELISA kit that detects TNFSF11/RANKL in blood samples of mice is now available. The kit's sensitivity is exceptional and is compatible with other ELISA kits. It is recommended for use in studies that involve bone marrow cells.
PMID: 9367155 by Anderson D.M., et al. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
PMID: 9568710 by Lacey D.L., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page