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- Table of Contents
TRAF6 Antibodies
AND TRAF6 ELISA kits, TRAF6 Proteins
Many biological assays use antibodies to detect TRAF6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRAF6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRAF6 antibodies...
Designing an IHC experiment for TRAF6? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TRAF6 IHC GuideTRAF6 Infographic by Boster Bio
All TRAF6 Products
Product
Figures
Specificity
Applications
Price
Anti-TRAF6 Antibody Picoband®
11 Citations
Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00185
100 μg/vial
Cat # A00185
100 μg/vial
Anti-TRAF6 Rabbit Monoclonal Antibody
12 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00185
100 μl
Cat # M00185
100 μl
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M00185-1
100 μl
Cat # M00185-1
100 μl
TRAF6 Overview
Facts about TNF receptor-associated factor 6.
TNF receptor-associated factor 6 (TRAF6)
Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN.
May be essential for the creation of functional osteoclasts.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRAF6 |
| Uniprot: | Q9Y4K3 |
| Entrez: | 7189 |
Family
| Belongs to: |
|---|
| TNF receptor-associated factor family |
Alternative Names
E3 ubiquitin-protein ligase TRAF6; EC 6.3.2.-; Interleukin-1 signal transducer; RING finger protein 85; RNF85MGC:3310; TNF receptor-associated factor 6; TRAF6; TRAF-6
Molecular Weight
Mass (kDA):
59.573 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p12 |
| Sequence: | 11; NC_000011.10 (36483769..36510313, complement) |
Tissue Specificity
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Subcellular Localizations
Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet. Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity).
Diseases
- Inflammation
- Malignant Neoplasms
- Neoplasms
- Innate Immune Response
- Arthritis
- Autoimmune Reaction
- Inflammatory Response
- Autoimmune Diseases
- Rheumatoid Arthritis
- Virus Diseases
- Lymphoma
- Cell Transformation, Neoplastic
- Osteoporosis
Interacting Proteins
- CD40
- Ecsit
- EDA2R
- EDARADD
- IL1R1
- IRAK1
- IRAK2
- MALT1
- MAP3K14
- MAP3K7
Pathways
- Osteoclast Differentiation
- Immune Response
- Pathogenesis
- Secretion
- Bone Resorption
- Cytokine Production
- Inflammatory Response
- Cell Death
- Rna Interference
- Localization
- Cell Proliferation
- Innate Immune Response
- Cell Activation
PTMs
- Phosphorylation
- Ubiquitination
- Cleavage
- Methylation
- Sumoylation
- Biotinylation
- Glutathionylation
- Oxidation
Research Areas
- Immunology
- Innate Immunity
- Signal Transduction
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAF6
bosterbio.com/bosterbio-gene-info-cards/TRAF6
References
PMID: 8837778 by Cao Z., et al. TRAF6 is a signal transducer for interleukin-1.
PMID: 9020361 by Malinin N.L., et al. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.
5 Publications of Boster TRAF6 Antibodies & ELISA Kits
- PubMed ID: 10.12659/MSM.929438, Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4...
- PubMed ID: 10.1128/IAI.00585-21, microRNA-20-1 and miR-101a suppress the NF-κB-mediated inflammation production ...
- PubMed ID: 32855700, Liu L,Liu F,Sun Z,Peng Z,You T,Yu Z. LncRNA NEAT1 promotes apoptosis and inflamm...
- PubMed ID: 25269519, Liu Mw, Wang Yh, Qian Cy, Li H. Int J Mol Med. 2014 Dec;34(6):1492-504. Doi: 10....
- PubMed ID: 25202335, Yuan Z, Zhang J, Yang C. Evid Based Complement Alternat Med. 2014;2014:620359. D...
*More publications can be found for each product on its corresponding product page