WDR74 Antibodies

AND WDR74 ELISA kits, WDR74 Proteins

Many biological assays use antibodies to detect WDR74, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WDR74 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WDR74 antibodies...

We validate the specificity of these antibodies to WDR74 by testing them on tissues known to express WDR74 positively and negatively. Browse below to find the WDR74 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WDR74 Infographic by Boster Bio

All WDR74 Products

Product

Figures

Specificity

Applications

Price

Anti-NSA1 WDR74 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A14044
0.1 mg

Anti-WDR74 Mouse Monoclonal Antibody [Clone ID: OTI4B2]

Dog, Human, Monkey, Mouse, Rat

IHC, WB

$523
Cat # M14044
100 µl

WDR74 (NM_018093) Human Over-expression Lysate

Human

$628
Cat # LS054663
100 µg

WDR74 Overview

Facts about WD repeat-containing protein 74.

WDR74 3D structure. Source: alphafold

WD repeat-containing protein 74 (WDR74)

Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit (PubMed:26456651). Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (PubMed:29107693).

Required for blastocyst formation, is crucial for RNA transcription, processing and/or stability throughout preimplantation development (By similarity). .

Gene Information

Human
Gene Name:	WDR74
Uniprot:	Q6RFH5
Entrez:	54663

Family

Belongs to:

No superfamily

Alternative Names

FLJ10439; FLJ21730; NOP seven-associated protein 1; NSA1; WD repeat domain 74; WD repeat-containing protein 74

Molecular Weight

Mass (kDA):
42.441 kDA

Genomic Context


Human

Location:	11q12.3
Sequence:	11; NC_000011.10 (62832905..62841809, complement)

Subcellular Localizations

Nucleus, nucleolus. Nucleus. Nucleolar location depends on active PolI transcription of pre-rRNA.

Diseases

Adenocarcinoma
Neoplasm Metastasis
Animal Mammary Neoplasms
Malignant Neoplasms
Lung Neoplasms
Neoplasms
Metastatic Malignant Neoplasm To The Lung

Breast Adenocarcinoma

Interacting Proteins

RCHY1

Pathways

Blastocyst Formation
Cell Cycle

PTMs

Methylation

Phosphoprotein

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WDR74

References

PMID: 26456651 by Hiraishi N., et al. AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74.

PMID: 28416111 by Lo Y.H., et al. Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2.