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- Table of Contents
SMAD1 Antibodies
AND SMAD1 ELISA kits, SMAD1 Proteins
Many biological assays use antibodies to detect SMAD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMAD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMAD1 antibodies...
Designing a Western blot for SMAD1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SMAD1 Western Blot GuideDesigning an IHC experiment for SMAD1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SMAD1 IHC GuideSMAD1 Infographic by Boster Bio
All SMAD1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$370
Cat # P01423
100 μl
Cat # P01423
100 μl
Human, Mouse
ELISA
$540
Cat # EKC2272
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2272
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1958
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1958
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1833
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1833
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1526
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1526
1 kit, containing one 96-well plate and all necessary reagents
SMAD1 Overview
Facts about Mothers against decapentaplegic homolog 1.
Mothers against decapentaplegic homolog 1 (SMAD1)
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).
SMAD1/OAZ1/PSMB4 complex mediates the degradation of this CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMAD1 |
| Uniprot: | Q15797 |
| Entrez: | 4086 |
Family
| Belongs to: |
|---|
| dwarfin/SMAD family |
Alternative Names
BSP1; BSP-1; hSMAD1; JV4-1SMAD, mothers against DPP homolog 1 (Drosophila); MAD homolog 1; MADH1JV41; MADR1MAD, mothers against decapentaplegic homolog 1 (Drosophila); Mad-related protein 1; mothers against decapentaplegic homolog 1; Mothers against DPP homolog 1; SMAD family member 1SMAD 1; SMAD, mothers against DPP homolog 1; Smad1; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1
Molecular Weight
Mass (kDA):
52.26 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q31.21 |
| Sequence: | 4; NC_000004.12 (145481306..145559176) |
Tissue Specificity
Ubiquitous. Highest expression seen in the heart and skeletal muscle.
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity).
Diseases
- Malignant Neoplasms
- Neoplasms
- Fibrosis
- Kidney Diseases
- Hypertensive Disease
- Tumor Angiogenesis
- Nervousness
- Hypertrophy
- Idiopathic Pulmonary Hypertension
- Carcinoma
- Diabetic Nephropathy
- Pulmonary Hypertension
- Inflammation
Interacting Proteins
- AR
- CTDSP1
- CTDSP2
- CTDSPL
- DDX5
- DROSHA
- GSK3B
- IPO8
- LEMD3
- SMAD4
Pathways
- Osteoblast Differentiation
- Cell Proliferation
- Pathogenesis
- Cell Differentiation
- Localization
- Angiogenesis
- Cell Cycle
- Cell Growth
- Bmp Signaling Pathway
- Gastrulation
- Ossification
- Secretion
- Regeneration
PTMs
- Phosphorylation
- Ubiquitination
- Dephosphorylation
- Cleavage
- Methylation
- Iodination
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMAD1
bosterbio.com/bosterbio-gene-info-cards/SMAD1
References
PMID: 8673135 by Riggins G.J., et al. Mad-related genes in the human.
PMID: 8637600 by Liu F., et al. A human Mad protein acting as a BMP-regulated transcriptional activator.
6 Publications of Boster SMAD1 Antibodies & ELISA Kits
- PubMed ID: 10.3389/fphar.2021.643489, Inhibition of TMEM16A by Natural Product Silibinin: Potential Lead Compounds for...
- PubMed ID: 25356121, Shi K, Jiang J, Ma T, Xie J, Duan L, Chen R, Song P, Yu Z, Liu C, Zhu Q, Zheng J...
- PubMed ID: 21693312, Tao Y, Hu L, Li S, Liu Q, Wu X, Li D, Fu P, Wei D, Luo Z. Transplant Proc. 2011 ...
- PubMed ID: 22549392, Chen Wh, Kong Xy, Wan R, Xiao Cs, Li L, Wang Zy, Lin N, Wang Hm. Chin J Integr M...
- PubMed ID: 24746831, Tang Y, Li Y, Yu H, Gao C, Liu L, Chen S, Xing M, Liu L, Yao P. J Nutr Biochem. ...
- PubMed ID: 25820389, Xu T, Ni Mm, Huang C, Meng Xm, He Yh, Zhang L, Li J. Inflammation. 2015 Oct;38(5...
*More publications can be found for each product on its corresponding product page