Recombinant Human OSM Protein

Oncostatin-M (OSM) is amember of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophagecolony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Product Info Summary

SKU: R00804
Size: 100μg/vial
Origin Species: Human
Source: E. coli A26-R221

Product Name

Recombinant Human OSM Protein

See all Oncostatin M/OSM products

SKU/Catalog Number

R00804

Size

100μg/vial

Form

Lyophilized

Description

Oncostatin-M (OSM) is amember of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophagecolony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Storage & Handling

Lyophilized recombinant human Oncostatin-M remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, OSM remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

Cite This Product

Recombinant Human OSM Protein (Boster Biological Technology, Pleasanton CA, USA, Catalog # R00804)

Formulation

Reconstitute in ddH2O at 100 μg/mL.

Predicted MW

28.484kDa

Endotoxin

Less than 1 EU/μg of OSM as determined by LAL method.

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Validation Images & Assay Conditions

Gene/Protein Information For OSM (Source: Uniprot.Org, NCBI)

Uniprot ID

P13725

Gene ID

5008

Gene Name

OSM

Full Name

Oncostatin-M

Weight

28.484kDa

Superfamily

LIF/OSM family

Alternative Names

MGC20461; oncostatin M; oncostatin-M; OSM OSM oncostatin M oncostatin-M

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on OSM, check out the OSM Infographic

OSM infographic

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In this infographic you will see the following information for OSM: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

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