Anti-ARTS-1 ERAP1 Antibody

Product Name

Anti-ARTS-1 ERAP1 Antibody

View all Aminopeptidase PILS/ARTS1 Antibodies

SKU/Catalog Number

A02021

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-ARTS-1 ERAP1 Antibody (Catalog # A02021). Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-ARTS-1 ERAP1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02021)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human ARTS-1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02021 is reactive to ERAP1 in Human, Mouse, Rat

Applications

A02021 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

107.235kDa

Background of Aminopeptidase PILS/ARTS1

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Hattori A., J. Biochem. 130:235-241(2001).
Nakajima D., DNA Res. 9:99-106(2002).
Clark H.F., Genome Res. 13:2265-2270(2003).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

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Western blot analysis of extracts from HepG2 cells, Jurkat cells and HUVEC cells, using ARTS-1 antibody A02021.

Gene/Protein Information For ERAP1 (Source: Uniprot.org, NCBI)

Alternative Names

Adipocyte-derived leucine aminopeptidase; A-LAP; A-LAPALAP; Aminopeptidase PILS; ARTS1; ARTS1aminopeptidase regulator of TNFR1 shedding; ARTS-1PILSAP; EC 3.4.11; EC 3.4.11.-; EC 3.4.11.1; endoplasmic reticulum aminopeptidase 1; endoplasmic reticulum aminopeptidase associated with antigen processing; ERAAP1; ERAP1; KIAA0525APPILS; PILS-AP; PILS-APERAAP; Puromycin-insensitive leucyl-specific aminopeptidase; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator ERAP1 A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP, PILSAP endoplasmic reticulum aminopeptidase 1 endoplasmic reticulum aminopeptidase 1|CTD-2260A17.2|adipocyte-derived leucine aminopeptidase|aminopeptidase PILS|aminopeptidase regulator of TNFR1 shedding|endoplasmic reticulum aminopeptidase associated with antigen processing|puromycin-insensitive leucyl-specific aminopeptidase|type 1 tumor necrosis factor receptor shedding aminopeptidase regulator

For more info on ERAP1, check out the ERAP1 Infographic

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In this infographic, you will see the following information for ERAP1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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