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Product Info Summary
| SKU: | PA1592 |
|---|---|
| Size: | 100 μg/vial |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | IHC, WB |
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Product info
Product Name
Anti-CD168/HMMR Antibody
View all RHAMM/CD168 Antibodies
SKU/Catalog Number
PA1592
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-CD168/HMMR Antibody catalog # PA1592. Tested in IHC, WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-CD168/HMMR Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1592)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human CD168.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA1592 is reactive to HMMR in Human
Applications
PA1592 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
84 kDa
Calculated molecular weight
84.1kDa
Background of RHAMM/CD168
HMMR, Hyaluronan-mediated motility receptor, is a protein which in humans is encoded by the HMMR gene. RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan, HMMR is less well studied than the main hyaluronan (HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum/Golgi complex, HMMR does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence. HMMR normally is localized inside the cell and is only release by certain, poorly defined stimuli. The transport of HMMR to the extracellular space still is unclear but may involve transport channels or proteins, flippase activity, or exocytosis. Intracellularly, HMMR associates with microtubules and, working with BRCA1 and BARD1, plays a role in the regulation of mitosis. Extracellularly, HMMR associates with CD44, and upon binding to HA, activates intracellular signaling pathways. Variants of HMMR caused by alternative splicing have been observed, but not thoroughly studied.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Innovating Scientists Reward
If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.
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Assay dilution & Images
Reconsitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
Validation Images & Assay Conditions
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Anti-CD168 antibody, PA1592, Western blotting
Lane 1: MM231 Cell Lysate
Lane 2: MM453 Cell Lysate
Lane 3: HELA Cell Lysate
Lane 4: A549 Cell Lysate
Click image to see more details
Anti-CD168 antibody, PA1592, IHC(P)
IHC(P): Human Placenta Tissue
Protein Target Info & Infographic
Gene/Protein Information For HMMR (Source: Uniprot.org, NCBI)
Gene Name
HMMR
Full Name
Hyaluronan mediated motility receptor
Weight
84.1kDa
Alternative Names
CD168 antigen; CD168; HMMR; hyaluronan mediated motility receptor; hyaluronan-mediated motility receptor (RHAMM); IHABP; Intracellular hyaluronic acid-binding protein; MGC119494; Receptor for hyaluronan-mediated motility; RHAMM; RHAMMMGC119495 HMMR CD168, IHABP, RHAMM hyaluronan mediated motility receptor hyaluronan mediated motility receptor|intracellular hyaluronic acid-binding protein|receptor for hyaluronan-mediated motility
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on HMMR, check out the HMMR Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for HMMR: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CD168/HMMR Antibody (PA1592)
Hello CJ!
PA1592 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
RHAMM Expression in the Rat Endometrium during the Estrous Cycle and following Implantation
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Customer Reviews
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Customer Q&As
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1 Customer Q&As for Anti-CD168/HMMR Antibody
Question
We are currently using anti-CD168/HMMR antibody PA1592 for human tissue, and we are satisfied with the WB results. The species of reactivity given in the datasheet says human. Is it possible that the antibody can work on primate tissues as well?
Verified Customer
Verified customer
Asked: 2017-12-19
Answer
The anti-CD168/HMMR antibody (PA1592) has not been validated for cross reactivity specifically with primate tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in primate you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2017-12-19
