Rabbit IgG polyclonal antibody for Hyaluronan mediated motility receptor(HMMR) detection. Tested with WB, IHC-P in Human. Cited in 1 publication(s).
Anti-CD168/HMMR Antibody Info At A Glance
NAGK is a member of the eukaryotic-type N-acetylglucosamine kinase family. NAGK converts endogenous N-acetylglucosamine (GlcNAc), a key component of complex carbohydrates, from lysosomal degradation or alimentary sources into GlcNAc 6-phosphate. NAGK is a prominent salvage enzyme of amino sugar metabolism in mammals. NAGK cooperates with STK16 and LNX1 and has ManNAc kinase activity.
|Product Name||Anti-CD168/HMMR Antibody
See all RHAMM/CD168 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for CD168/HMMR detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. CD168/HMMR information: Molecular Weight: 84100 MW; Subcellular Localization: Cell surface. Cytoplasm .|
|Cite This Product||Anti-CD168/HMMR Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1592)|
|Similar Products From
|Anti-CD168/HMMR Antibody may replace the following items: sc 16170|sc 25488.|
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human CD168(706-724aa KEGNTNCYRAPMECQESWK).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For HMMR (Source: Uniprot.org, NCBI)
|NCBI Gene Id||3161|
|Species Of This Entry||Human|
|Protein Name||Hyaluronan mediated motility receptor|
|Alternative Names||RHAMM/CD168|CD168 antigen; CD168; HMMR; hyaluronan mediated motility receptor; hyaluronan-mediated motility receptor (RHAMM); IHABP; Intracellular hyaluronic acid-binding protein; MGC119494; Receptor for hyaluronan-mediated motility; RHAMM; RHAMMMGC119495|
|Post Tranlational Modifications||Oxidation; Ubiquitination|
|Subcellular Localization||Cell surface. Cytoplasm.|
|Gene Location||5q34, on Chromasome 5, gene sequence: NC_000005.10 (163460632..163491941)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For HMMR (Source: Uniprot.org, NCBI)
|Protein Function||Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).|
|Interacting Proteins||BRCA1; MORN4; TPX2|
|Related Diseases||Malignant Neoplasms; Neoplasms; Mammary Neoplasms; Malignant Neoplasm Of Breast; Leukemia; Neoplasm Metastasis; Myeloid Leukemia; Leukemia, Myelocytic, Acute; Cell Invasion; Neoplasm Invasiveness; Carcinoma; Tissue Adhesions; Peripheral Nerve Sheath Neoplasm; Headache; Nerve Sheath Tumors; Adenocarcinoma; Neurofibroma; Neurofibromatosis 1; Malignant Paraganglionic Neoplasm|
|Related Pathways||Cell Cycle; Cell Proliferation; Cell Motility; Pathogenesis; Cell Adhesion; Transport; Cell Migration; Localization; Mitosis; Immune Response; Extracellular Transport; Metaphase; Senescence; Cell Division; Spindle Checkpoint; Cell Death; Biological Regulation; Dedifferentiation; Cell Growth; Oxygen Transport|
|Background||HMMR, Hyaluronan-mediated motility receptor, is a protein which in humans is encoded by the HMMR gene. RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan, HMMR is less well studied than the main hyaluronan(HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum/Golgi complex, HMMR does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence. HMMR normally is localized inside the cell and is only release by certain, poorly defined stimuli. The transport of HMMR to the extracellular space still is unclear but may involve transport channels or proteins, flippase activity, or exocytosis. Intracellularly, HMMR associates with microtubules and, working with BRCA1 and BARD1, plays a role in the regulation of mitosis. Extracellularly, HMMR associates with CD44, and upon binding to HA, activates intracellular signaling pathways. Variants of HMMR caused by alternative splicing have been observed, but not thoroughly studied.|
|Scientific References||PMID: 8890751 by Wang C., et al. The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains.|
PMID: 9601098 by Assmann V., et al. The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells.
Our Boster Quality Guarantee for Anti-CD168/HMMR Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: MM231 Cell Lysate
Lane 2: MM453 Cell Lysate
Lane 3: HELA Cell Lysate
Lane 4: A549 Cell Lysate
IHC(P): Human Placenta Tissue
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