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Product Info Summary
| SKU: | A07351 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-Centromere protein W CENPW Antibody
SKU/Catalog Number
A07351
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Centromere protein W CENPW Antibody (Catalog # A07351). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CENPW antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Centromere protein W CENPW Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07351)
Host
Rabbit
Contents
CENPW Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
CENPW antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CENPW. The immunogen is located within the first 50 amino acids of CENPW.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of CENPW are known to exist; this antibody will detect all three isoforms.
Reactive Species
A07351 is reactive to Cenpw in Human, Mouse, Rat
Applications
A07351 is guaranteed for ELISA, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
9.734kDa
Background of Cenpw
CENPW was initially identified as a gene that was upregulated in multiple cancers, and whose overexpression in mouse fibroblast cells gave rise to distinct cancer-specific phenotypes. It was later found to be a nuclear protein that associated with CENPT, a component of CENPA nucleosome complex in the centromere, and is required for proper kinetochore function. CENPW also specifically interacts with the nucleolar phosphoprotein nucleophosmin, also known as B23 It has been suggested that nucleophosmin functions in the assembly of the kinetochore by interacting with CENPW during interphase. Overexpression of CENPW in the SKOV-3 human ovarian cancer cell line as well as in the zebrafish embryo led to apoptosis, suggesting that high levels of CENPW induces apoptotic cell death.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CENPW antibody can be used for detection of CENPW by Western blot at 0.5 - 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CENPW in HeLa cell lysate lysate with CENPW antibody at (A) 0.5 and (B) 1 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Cenpw (Source: Uniprot.org, NCBI)
Gene Name
Cenpw
Full Name
Centromere protein W
Weight
9.734kDa
Superfamily
CENP-W/WIP1 family
Alternative Names
cancer-up-regulated gene 2 protein; centromere protein W
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Cenpw, check out the Cenpw Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Cenpw: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Centromere protein W CENPW Antibody (A07351)
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