Product Info Summary
SKU: | M00787 |
---|---|
Size: | 100ul |
Reactive Species: | Human |
Host: | Mouse |
Application: | IP, WB |
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Product info
Product Name
Anti-DNA repair protein XRCC4 XRCC4 Monoclonal Antibody
SKU/Catalog Number
M00787
Size
100ul
Form
Liquid
Description
Boster Bio Anti-DNA repair protein XRCC4 XRCC4 Monoclonal Antibody catalog # M00787. Tested in IP, WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-DNA repair protein XRCC4 XRCC4 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00787)
Host
Mouse
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Monoclonal
Clone Number
5C10
Isotype
IgG
Immunogen
Synthetic Peptide
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
M00787 is reactive to XRCC4 in Human
Applications
M00787 is guaranteed for IP, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
38.287kDa
Background of XRCC4
TRPC6, also known as TRP6, short transient receptor potential channel 6 and transient receptor potential cation channel subfamily C member 6, is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC6 is probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. It is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C and may not to be activated by intracellular calcium store depletion. Defects in this gene are a cause of focal segmental glomerulosclerosis (FSGS). Expression of this protein has been reported in tissues such as placenta, lung, spleen, ovary, small intestine, and renal podocytes. Immunohistochemistry studies using polyclonal antibodies to this target have shown moderate to strong staining in cell types such as neurons, breast, respiratory, squamous and prostate epithelium, epidermis, placental trophoblasts, dendritic cells, and subsets of immune cells, and faint to moderate staining of adrenal, colon, ganglion cells, hepatocytes, heart, and testis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:2000
IP 1:200
Validation Images & Assay Conditions
Click image to see more details
Figure 2. Immunohistochemistry validation of XRCC4 using Anti-DNA repair protein XRCC4 XRCC4 Monoclonal Antibody (M00787).
Immunohistochemical analysis of human-breast-cancer tissue. Anti-XRCC4 at 1:200 (4°CClick image to see more details
Figure 3. Immunohistochemistry validation of XRCC4 using Anti-DNA repair protein XRCC4 XRCC4 Monoclonal Antibody (M00787).
Immunohistochemical analysis of human kidney tissue. Anti-XRCC4 at 1:200 (4°CClick image to see more details
Figure 4. Immunohistochemistry validation of XRCC4 using Anti-DNA repair protein XRCC4 XRCC4 Monoclonal Antibody (M00787).
Immunohistochemical analysis of human liver cancer tissue. Anti-XRCC4 at 1:200 (4°CClick image to see more details
Figure 5. Immunohistochemistry validation of XRCC4 using Anti-DNA repair protein XRCC4 XRCC4 Monoclonal Antibody (M00787).
Immunohistochemical analysis of human lung cancer tissue. Anti-XRCC4 at 1:200 (4°CClick image to see more details
Figure 6. IP validation of XRCC4 using Anti-DNA repair protein XRCC4 XRCC4 Monoclonal Antibody (M00787).
Immunoprecipitation (IP) analysis: 1) Input: HeLa Cell Lysate.Click image to see more details
Figure 1. Western blotting validation for Anti-DNA repair protein XRCC4 XRCC4 Monoclonal Antibody M00787
Western blot (WB) analysis of XRCC4 monoclonal antibody.Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For XRCC4 (Source: Uniprot.org, NCBI)
Gene Name
XRCC4
Full Name
DNA repair protein XRCC4
Weight
38.287kDa
Superfamily
XRCC4 family
Alternative Names
complementing defective, repair in Chinese hamster; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross-complementing protein 4 XRCC4 SSMED X-ray repair cross complementing 4 DNA repair protein XRCC4|X-ray repair complementing defective repair in Chinese hamster cells 4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on XRCC4, check out the XRCC4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for XRCC4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-DNA repair protein XRCC4 XRCC4 Monoclonal Antibody (M00787)
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No publications found for M00787
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