Anti-Hu CD108 Purified SEMA7A Monoclonal Antibody

Product Name

Anti-Hu CD108 Purified SEMA7A Monoclonal Antibody

View all Semaphorin 7A Antibodies

SKU/Catalog Number

M03832

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Hu CD108 Purified SEMA7A Monoclonal Antibody (Catalog# M03832). Tested in Flow Cytometry, IP, WB application(s). This antibody reacts with Human.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-Hu CD108 Purified SEMA7A Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M03832)

Host

Mouse

Contents

Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

MEM-150

Isotype

Mouse IgM

Immunogen

HPB-ALL human T cell line. The antibody MEM-150 reacts with CD108 (JMH blood group antigen), a 80 kDa GPI-anchored extracellular glycoprotein expressed on various cell types including erythrocytes, lymphoblasts; at low levels it is present on circulating lymphocytes.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

This antibody does not cross-react with Thy-1.1 alloantigen.

Reactive Species

M03832 is reactive to SEMA7A in Human

Applications

M03832 is guaranteed for Flow Cytometry, IP, WB Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

74.824kDa

Background of Semaphorin 7A

CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes through its receptors –; plexin C1 and beta1 integrins.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow cytometry: 4 μg/ml.
Western blotting: Non-reducing conditions.

Validation Images & Assay Conditions

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Figure 1. Flow Cytometry validation of SEMA7A using Anti-Hu CD108 Purified SEMA7A Monoclonal Antibody (M03832).

Flow cytometry analysis (surface staining) of human peripheral blood with anti-human CD108 (MEM-150) purified

Gene/Protein Information For SEMA7A (Source: Uniprot.org, NCBI)

Alternative Names

CD108 antigen; CD108; CD108MGC126696; CDw108; H-SEMA-K1; H-Sema-L; JMH blood group antigen; JMH; John-Milton-Hargen human blood group Ag; MGC126692; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin)7A (JMH blood group); sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin)7A; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A; Sema K1; Sema L; Sema7A; SEMAK1; SEMAL; SEMALJohn Milton Hagen blood group H-Sema K1; Semaphorin 7A; semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group); semaphorin K1; semaphorin L; s SEMA7A CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL semaphorin 7A (John Milton Hagen blood group) semaphorin-7A|JMH blood group antigen|John Milton Hagen blood group H-Sema K1|john-Milton-Hargen human blood group Ag|sema K1|sema L|sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group)|sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A|semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)|semaphorin-K1|semaphorin-L

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