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Product Info Summary
| SKU: | A02289 |
|---|---|
| Size: | 100 µl |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | IF, IHC, WB |
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Product info
Product Name
Anti-Keratin 17 KRT17 Antibody
SKU/Catalog Number
A02289
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-Keratin 17 KRT17 Antibody (Catalog # A02289). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Keratin 17 KRT17 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02289)
Host
Rabbit
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human keratin 17.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A02289 is reactive to KRT17 in Human, Mouse, Rat
Applications
A02289 is guaranteed for IF, IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
48.106kDa
Background of KRT17
May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair By similarity.
M Rosenberg, Mol. Cell. Biol., Feb 1988; 8: 722 - 736.
SM Troyanovsky, J. Cell Sci., Jul 1989; 93: 419.
Kevin M. McGowan, Genes & Dev., Jun 2002; 16: 1412.
Nicholas Bianchi, Mol. Cell. Biol., Aug 2005; 25: 7249 - 7259.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500
Validation Images & Assay Conditions
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using keratin 17 antibody A02289.
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Western blot analysis of extracts from HuvEc cells, using keratin 17 antibody A02289.
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Immunofluorescence analysis of HepG2 cells, using keratin 17 antibody A02289.
Protein Target Info & Infographic
Gene/Protein Information For KRT17 (Source: Uniprot.org, NCBI)
Gene Name
KRT17
Full Name
Keratin, type I cytoskeletal 17
Weight
48.106kDa
Superfamily
intermediate filament family
Alternative Names
39.1; CK-17; cytokeratin-17; K17; keratin 17; keratin, type I cytoskeletal 17; keratin-17; PC; PC2; PCHC1 KRT17 39.1, CK-17, K17, PC, PC2, PCHC1 keratin 17 keratin, type I cytoskeletal 17|cytokeratin-17|keratin 17, type I
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on KRT17, check out the KRT17 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for KRT17: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Keratin 17 KRT17 Antibody (A02289)
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No publications found for A02289
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