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Product Info Summary
| SKU: | A02124 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-NALP12 NLRP12 Antibody
SKU/Catalog Number
A02124
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-NALP12 NLRP12 Antibody (Catalog # A02124). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
NALP12 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-NALP12 NLRP12 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02124)
Host
Rabbit
Contents
NALP12 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
NALP12 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP12. The immunogen is located within amino acids 110 - 160 of NALP12.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TRIM21 antibody is human specific. This antibody is predicted to not cross-react with TRIM6.
Reactive Species
A02124 is reactive to NLRP12 in Human, Mouse, Rat
Applications
A02124 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
120.173kDa
Background of NALP12
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-κB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
NALP12 antibody can be used for detection of NALP12 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of NALP12 in human brain tissue lysate with NALP12 antibody at 1 μg/mL.
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Immunohistochemistry of NALP12 in human brain tissue with NALP12 antibody at 5 μg/mL.
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Immunofluorescence of NALP12 in human brain tissue with NALP12 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For NLRP12 (Source: Uniprot.org, NCBI)
Gene Name
NLRP12
Full Name
NACHT, LRR and PYD domains-containing protein 12
Weight
120.173kDa
Superfamily
NLRP family
Alternative Names
FCAS2; Monarch-1; NACHT, leucine rich repeat and PYD containing 12; NACHT, LRR and PYD domains-containing protein 12; NALP12LRR and PYD containing protein 12; NLR family, pyrin domain containing 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 12; PYPAF7Monarch1; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide; RNO2 NLRP12 CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2 NLR family pyrin domain containing 12 NACHT, LRR and PYD domains-containing protein 12|PYRIN-containing APAF1-like protein 7|monarch 1|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12|regulated by nitric oxide
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NLRP12, check out the NLRP12 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NLRP12: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-NALP12 NLRP12 Antibody (A02124)
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No publications found for A02124
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