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- Table of Contents
AKT3 Antibodies
AND AKT3 ELISA kits, AKT3 Proteins
Many biological assays use antibodies to detect AKT3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AKT3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AKT3 antibodies...
Designing a Western blot for AKT3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the AKT3 Western Blot GuideDesigning an IHC experiment for AKT3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the AKT3 IHC GuideAKT3 Infographic by Boster Bio
All AKT3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00024-8
20μL, 40μL, 100μL, 200μL
Cat # M00024-8
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00024-9
20μL, 40μL, 100μL, 200μL
Cat # M00024-9
20μL, 40μL, 100μL, 200μL
AKT3 Overview
Facts about RAC-gamma serine/threonine-protein kinase.
RAC-gamma serine/threonine-protein kinase (AKT3)
AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes such as metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates.
Over 100 substrate candidates have been reported so far, but for many of them, no isoform specificity was reported. AKT3 is the least researched AKT isoform.
Gene Information
| Human | |
|---|---|
| Gene Name: | AKT3 |
| Uniprot: | Q9Y243 |
| Entrez: | 10000 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Akt3; Akt-3; EC 2.7.11; EC 2.7.11.1; PKB gamma; PKBGDKFZp434N0250; PRKBG; RAC-gamma; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Molecular Weight
Mass (kDA):
55.775 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q43-q44 |
| Sequence: | 1; NC_000001.11 (243488233..243851079, complement) |
Tissue Specificity
In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
Subcellular Localizations
Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Membrane-associated after cell stimulation leading to its translocation.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Melanoma
- Cell Invasion
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Tumor Progression
- Malignant Neoplasm Of Prostate
- Skin Neoplasms
Interacting Proteins
- CASP3
- CDC37
Pathways
- Cell Proliferation
- Cell Growth
- Cell Death
- Cell Cycle
- Angiogenesis
- Pathogenesis
- Transport
- Localization
- Cell Migration
- Cell Motility
- Brain Development
- Rna Interference
- Glucose Homeostasis
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Methylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AKT3
bosterbio.com/bosterbio-gene-info-cards/AKT3
References
PMID: 10092583 by Brodbeck D., et al. A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain.
PMID: 10208883 by Nakatani K., et al. Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.