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- Table of Contents
Facts about RAC-gamma serine/threonine-protein kinase.
Over 100 substrate candidates have been reported so far, but for many of them, no isoform specificity was reported. AKT3 is the least researched AKT isoform.
Human | |
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Gene Name: | AKT3 |
Uniprot: | Q9Y243 |
Entrez: | 10000 |
Belongs to: |
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protein kinase superfamily |
Akt3; Akt-3; EC 2.7.11; EC 2.7.11.1; PKB gamma; PKBGDKFZp434N0250; PRKBG; RAC-gamma; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Mass (kDA):
55.775 kDA
Human | |
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Location: | 1q43-q44 |
Sequence: | 1; NC_000001.11 (243488233..243851079, complement) |
In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Membrane-associated after cell stimulation leading to its translocation.
PMID: 10092583 by Brodbeck D., et al. A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain.
PMID: 10208883 by Nakatani K., et al. Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.