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- Table of Contents
Aquaporin-4 Antibodies
AND AQP4 ELISA kits, Aquaporin-4 Proteins
Many biological assays use antibodies to detect Aquaporin-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Aquaporin-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Aquaporin-4 antibodies...
Designing a Western blot for Aquaporin-4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the AQP4 Western Blot GuideAQP4 Infographic by Boster Bio
All AQP4 Products
Product
Figures
Specificity
Applications
Price
Anti-Aquaporin 4/AQP4 Antibody Picoband®
11 Citations
Human, Mouse, Rat, Zebrafish
IHC, WB
$370
Cat # PB9475
100 μg/vial
Cat # PB9475
100 μg/vial
Anti-Aquaporin 4/AQP4 Antibody Picoband®
4 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1937
100 μg/vial
Cat # PA1937
100 μg/vial
Anti-Aquaporin 4/AQP4 Antibody Picoband®
3 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01049
100 μg/vial
Cat # A01049
100 μg/vial
AQP4 Overview
Facts about Aquaporin-4.
Aquaporin-4 (AQP4)
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | AQP4 |
| Uniprot: | P55087 |
| Entrez: | 361 |
Family
| Belongs to: |
|---|
| MIP/aquaporin (TC 1.A.8) family |
Alternative Names
aquaporin 4; MGC22454
Molecular Weight
Mass (kDA):
34.83 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q11.2 |
| Sequence: | 18; NC_000018.10 (26852038..26865803, complement) |
Tissue Specificity
Brain - muscle >> heart, kidney, lung, and trachea.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Endosome membrane. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection. Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane. Detected on brain astrocyte processes and astrocyte endfeet close to capillaries.
Diseases
- Edema
- Neuromyelitis Optica
- Brain Edema
- Nervousness
- Multiple Sclerosis
- Sclerosis
- Myelitis
- Optic Neuritis
- Neuritis
- Demyelinating Diseases
- Brain Injuries
- Autoimmune Reaction
Pathways
- Transport
- Water Transport
- Localization
- Pathogenesis
- Water Homeostasis
- Secretion
- Fluid Transport
- Ion Homeostasis
- Cell Migration
- Cell Death
- Angiogenesis
- Cellular Localization
- Complement Activation
PTMs
- Phosphorylation
- Glycosylation
- Biotinylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AQP4
bosterbio.com/bosterbio-gene-info-cards/AQP4
References
PMID: 7559426 by Yang B., et al. cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units.
PMID: 8601457 by Misaka T., et al. A water channel closely related to rat brain aquaporin 4 is expressed in acid- and pepsinogen-secretory cells of human stomach.
12 Publications of Boster Aquaporin-4 Antibodies & ELISA Kits
- PubMed ID: PMID:24995117, Ulinastatin attenuates cerebral ischemia-reperfusion injury in rats
- PubMed ID: 10.3171/2008.4.JNS17512, Brain edema after intracerebral hemorrhage in rats: the role of iron overload an...
- PubMed ID: 10.1096/fj.202100673R, Group 2 innate lymphoid cells suppress the pathology of neuromyelitis optica spe...
- PubMed ID: 10.1080/09291016.2021.2007329, Expression of AQP1, AQP3, AQP4 and AQP5 in upper respiratory tract of buffaloes ...
- PubMed ID: 10.1055/s-0034-1368584, Neuroprotective effects of total steroid saponins on cerebral ischemia injuries ...
- PubMed ID: 10.1002/jcb.26176, Down‐Regulation of AQP4 Expression via p38 MAPK Signaling in Temozolomide‐In...
- PubMed ID: 33484756, Song T,Chen W,Chen X,Zhang H,Zou Y,Wu H,Lin F,Ren L,Kang Y,Lei H.Repeated fluoxe...
- PubMed ID: 29351212, Changes in the Expression of AQP4 and AQP9 in the Hippocampus Following Eclampsi...
- PubMed ID: 26261083, Expression pattern of aquaporins in patients with primary nephrotic syndrome wit...
- PubMed ID: 24963614, Neuroprotective effects of total steroid saponins on cerebral ischemia injuries ...
- PubMed ID: 29445328, Anzabi M, Ardalan M, Iversen NK, Rafati AH, Hansen B, ?stergaard L. Front Cell N...
- PubMed ID: 24995117, Chen Hm, Huang Hs, Ruan L, He Yb, Li Xj. Int J Clin Exp Med. 2014 May 15;7(5):14...
*More publications can be found for each product on its corresponding product page