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- Table of Contents
ARPC5 Antibodies
AND ARPC5 ELISA kits, ARPC5 Proteins
Many biological assays use antibodies to detect ARPC5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARPC5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARPC5 antibodies...
Designing an IHC experiment for ARPC5? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ARPC5 IHC GuideARPC5 Infographic by Boster Bio
All ARPC5 Products
Product
Figures
Specificity
Applications
Price
Anti-p16 ARC ARPC5 Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02096
100 μl
Cat # M02096
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02096-1
100 μg/vial
Cat # A02096-1
100 μg/vial
ARPC5 Overview
Facts about Actin-related protein 2/3 complex subunit 5.
Actin-related protein 2/3 complex subunit 5 (ARPC5)
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation- promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079).
Besides its function in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by encouraging nuclear actin polymerization, leading to drive motility of double- strand breaks (DSBs) (PubMed:29925947).
Gene Information
| Human | |
|---|---|
| Gene Name: | ARPC5 |
| Uniprot: | O15511 |
| Entrez: | 10092 |
Family
| Belongs to: |
|---|
| ARPC5 family |
Alternative Names
actin related protein 2/3 complex, subunit 5, 16kDa; ARC16subunit 5 (16 kD); MGC88523
Molecular Weight
Mass (kDA):
16.32 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q25.3 |
| Sequence: | 1; NC_000001.11 (183620846..183635783, complement) |
Subcellular Localizations
Cytoplasm, cytoskeleton. Cell projection. Nucleus.
Diseases
- Malignant Squamous Cell Neoplasm
- Carcinoma
- Malignant Neoplasms
- Neoplasms
- Wiskott-aldrich Syndrome
- Cell Invasion
- Cell Transformation, Neoplastic
- Lung Neoplasms
- Rhabdomyosarcoma
- Head And Neck Carcinoma
- Cholecystolithiasis
Pathways
- Actin Nucleation
- Transport
- Endocytosis
- Clathrin-mediated Endocytosis
- Cell Proliferation
- Smooth Muscle Contraction
- Cell Migration
- Muscle Contraction
- Spermatid Differentiation
- Spermatogenesis
- Translation
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARPC5
bosterbio.com/bosterbio-gene-info-cards/ARPC5
References
PMID: 9230079 by Welch M.D., et al. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.
PMID: 9359840 by Machesky L.M., et al. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins.