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- Table of Contents
BBC3 Antibodies
AND BBC3 ELISA kits, BBC3 Proteins
Many biological assays use antibodies to detect BBC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BBC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BBC3 antibodies...
Designing a Western blot for BBC3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BBC3 Western Blot GuideDesigning an IHC experiment for BBC3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the BBC3 IHC GuideBBC3 Infographic by Boster Bio
All BBC3 Products
Product
Figures
Specificity
Applications
Price
Anti-PUMA BBC3 Rabbit Monoclonal Antibody
3 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M04899
100 μl
Cat # M04899
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M04899-2
20μL, 40μL, 100μL, 200μL
Cat # M04899-2
20μL, 40μL, 100μL, 200μL
Human
$628
Cat # LS027113
20 µg, 100 µg
Cat # LS027113
20 µg, 100 µg
BBC3 Overview
Facts about Bcl-2-binding component 3, isoforms 3/4.
Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Isoform 3 fails to reveal some growth- inhibitory or apoptotic activity.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | BBC3 |
| Uniprot: | Q96PG8 |
| Entrez: | 27113 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BCL2 binding component 3; bcl-2-binding component 3; JFY1; JFY-1; p53 up-regulated modulator of apoptosis; PUMAFLJ42994
Molecular Weight
Mass (kDA):
26.498 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.32 |
| Sequence: | 19; NC_000019.10 (47220822..47232998, complement) |
Subcellular Localizations
Contrary to isoforms 1 and 2, isoform 3 does not localize to the mitochondria.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Leukemia
- Malignant Tumor Of Colon
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Colorectal Cancer
- Mammary Neoplasms
- Colorectal Neoplasms
- Malignant Paraganglionic Neoplasm
- Colonic Neoplasms
Pathways
- Cell Death
- Cell Cycle
- Induction Of Apoptosis
- Cell Cycle Arrest
- Cell Growth
- Rna Interference
- Cell Proliferation
- Mitochondrial Translocation
- Pathogenesis
- Sensitization
- Methylation
- Localization
- Autophagy
PTMs
- Phosphorylation
- Cleavage
- Acetylation
- Methylation
- Ubiquitination
Research Areas
- Apoptosis
- Cancer
- DNA Double Strand Break Repair
- Signal Transduction
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BBC3
bosterbio.com/bosterbio-gene-info-cards/BBC3
References
PMID: 11463392 by Nakano K., et al. PUMA, a novel proapoptotic gene, is induced by p53.
2 Publications of Boster BBC3 Antibodies & ELISA Kits
- PubMed ID: 25630785, Nerve growth factor reduces apoptotic cell death in rat facial motor neurons aft...
- PubMed ID: 21248471, Zhao Y, Wu S, Wu J, Jia P, Gao S, Yan X, Wang Y. Cancer Biol Ther. 2011 Jan 1;11...
*More publications can be found for each product on its corresponding product page