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- Table of Contents
Beclin-1 Antibodies
AND BECN1 ELISA kits, Beclin-1 Proteins
Many biological assays use antibodies to detect Beclin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Beclin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Beclin-1 antibodies...
Designing a Western blot for Beclin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BECN1 Western Blot GuideBECN1 Infographic by Boster Bio
All BECN1 Products
Product
Figures
Specificity
Applications
Price
Anti-Beclin 1/BECN1 Antibody Picoband®
44 Citations
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # PB9076
100 μg/vial
Cat # PB9076
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00327-2
100 μg/vial
Cat # M00327-2
100 μg/vial
Anti-Beclin 1 BECN1 Monoclonal Antibody
4 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00327
100 μl
Cat # M00327
100 μl
Human, Mouse, Rat
ELISA, IF, IHC-P, ICC, WB
$481
Cat # A00327-1
0.1 mg
Cat # A00327-1
0.1 mg
Dog, Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M00327-1
100 µl
Cat # M00327-1
100 µl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00327-4
20μL, 40μL, 100μL, 200μL
Cat # M00327-4
20μL, 40μL, 100μL, 200μL
BECN1 Overview
Facts about Beclin-1.
Beclin-1 (BECN1)
Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in several membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301).
Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521).
Gene Information
| Human | |
|---|---|
| Gene Name: | BECN1 |
| Uniprot: | Q14457 |
| Entrez: | 8678 |
Family
| Belongs to: |
|---|
| beclin family |
Alternative Names
ATG6 autophagy related 6 homolog; ATG6; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); Beclin 1; beclin 1, autophagy related; beclin1; beclin-1; BECN1; Coiled-coil myosin-like BCL2-interacting protein; GT197; Protein GT197; VPS30
Molecular Weight
Mass (kDA):
51.896 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.31 |
| Sequence: | 17; NC_000017.11 (42810132..42824316, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Endosome. Cytoplasmic vesicle, autophagosome. Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity).; [Beclin-1-C 35 kDa]: Mitochondrion. Nucleus. Cytoplasm.; [Beclin-1-C 37 kDa]: Mitochondrion.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Hypoxia
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Nerve Degeneration
- Liver Carcinoma
- Liver Neoplasms
Interacting Proteins
- AMBRA1
- ATG14
- BCL2
- BIRC5
- DAPK1
- EGFR
- EXOC8
- HMGB1
- HTT
- KRT18
Pathways
- Autophagy
- Cell Death
- Autophagic Cell Death
- Pathogenesis
- Macroautophagy
- Programmed Cell Death
- Cell Cycle
- Regulation Of Autophagy
- Cell Proliferation
- Cell Growth
- Rna Interference
- Cell Cycle Arrest
- Catabolic Process
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Methylation
- Dephosphorylation
- Reduction
Research Areas
- Apoptosis
- Autophagy
- Cancer
- HIF Target Genes
- Hypoxia
- Immunology
- Innate Immunity
- mTOR Pathway
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BECN1
bosterbio.com/bosterbio-gene-info-cards/BECN1
References
PMID: 9765397 by Liang X.H., et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein.
PMID: 10395800 by Aita V.M., et al. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21.
17 Publications of Boster Beclin-1 Antibodies & ELISA Kits
- PubMed ID: PMID:27293989, Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in...
- PubMed ID: 10.3892/ijo.2015.3039, Autophagy is involved in recombinant Newcastle disease virus (rL-RVG)-induced ce...
- PubMed ID: 10.3390/toxins13070503, The Protein-Independent Role of Phosphate in the Progression of Chronic Kidney D...
- PubMed ID: 10.1155/2021/5584447, Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyr...
- PubMed ID: 10.1007/s12288-019-01241-3, MicroRNA 30a Mediated Autophagy and Imatinib Response in Egyptian Chronic Myeloi...
- PubMed ID: 10.1002/iub.2539, Endogenous dipeptide-carnosine supplementation ameliorates hypobaric hypoxia-ind...
- PubMed ID: -, Gang Zhong,Huiping Long,Shiting Ma,Yao Shunhan,Jia Li,Jun Yao,miRNA-335-5p relie...
- PubMed ID: -, Zhiwei Liao,Suyun Li,Rong Liu,Xiaobo Feng,Yunsong Shi,Kun Wang,Shuai Li,Yukun Zh...
- PubMed ID: 33529908, Ni K,Hua Y.Hydrogen sulfide exacerbated periodontal inflammation and induced aut...
- PubMed ID: 31900522, Song L,Yao L,Zhang L,Piao Z,Lu Y.Schizandrol A protects against Aβ1-42-induced ...
- PubMed ID: 30016968, Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of c...
- PubMed ID: 28848439, Antagomirs Targeting MiroRNA-134 Attenuates Epilepsy in Rats through Regulation ...
- PubMed ID: 27464624, Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system ind...
- PubMed ID: 27293989, Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in...
- PubMed ID: 29725398, Qi QM, Xue YC, Lv J, Sun D, Du JX, Cai SQ, Li YH, Gu TC, Wang MB. Oncol Lett. 20...
- PubMed ID: 29651246, Wang G, Dai G, Song J, Zhu M, Liu Y, Hou X, Ke Z, Zhou Y, Qiu H, Wang F, Jiang N...
- PubMed ID: 29052054, Song J, Hu Y, Li J, Zheng H, Wang J, Guo L, Shi H, Liu L. Arch Virol. 2018 Jan;1...
*More publications can be found for each product on its corresponding product page