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- Table of Contents
Beclin-1 Antibodies
AND BECN1 ELISA kits, Beclin-1 Proteins
Many biological assays use antibodies to detect Beclin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Beclin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Beclin-1 antibodies...
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BECN1 Infographic by Boster Bio
All BECN1 Products
Product
Figures
Specificity
Applications
Price
Anti-Beclin 1/BECN1 Antibody Picoband®
9 Citations 16 Q&As
Human, Mouse, Rat
WB
$370
Cat # PA1847
100 μg/vial
Cat # PA1847
100 μg/vial
Anti-Beclin 1/BECN1 Antibody Picoband®
43 Citations 15 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # PB9076
100 μg/vial
Cat # PB9076
100 μg/vial
Anti-Beclin 1 BECN1 Monoclonal Antibody
4 Citations 16 Q&As
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00327
100 μl
Cat # M00327
100 μl
Human, Mouse, Rat
ELISA, IF, IHC-P, ICC, WB
$481
Cat # A00327-1
0.1 mg
Cat # A00327-1
0.1 mg
Dog, Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M00327-1
100 µl
Cat # M00327-1
100 µl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00327-2
100 μg/vial
Cat # M00327-2
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00327-4
20μL, 40μL, 100μL, 200μL
Cat # M00327-4
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # P00327-2
100 μl/vial
Cat # P00327-2
100 μl/vial
BECN1 Overview
Facts about Beclin-1.
Beclin-1 (BECN1)
Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in several membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301).
Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521).
Gene Information
| Human | |
|---|---|
| Gene Name: | BECN1 |
| Uniprot: | Q14457 |
| Entrez: | 8678 |
Family
| Belongs to: |
|---|
| beclin family |
Alternative Names
ATG6 autophagy related 6 homolog; ATG6; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); Beclin 1; beclin 1, autophagy related; beclin1; beclin-1; BECN1; Coiled-coil myosin-like BCL2-interacting protein; GT197; Protein GT197; VPS30
Molecular Weight
Mass (kDA):
51.896 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.31 |
| Sequence: | 17; NC_000017.11 (42810132..42824316, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Endosome. Cytoplasmic vesicle, autophagosome. Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity).; [Beclin-1-C 35 kDa]: Mitochondrion. Nucleus. Cytoplasm.; [Beclin-1-C 37 kDa]: Mitochondrion.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Hypoxia
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Nerve Degeneration
- Liver Carcinoma
- Liver Neoplasms
Interacting Proteins
- AMBRA1
- ATG14
- BCL2
- BIRC5
- DAPK1
- EGFR
- EXOC8
- HMGB1
- HTT
- KRT18
Pathways
- Autophagy
- Cell Death
- Autophagic Cell Death
- Pathogenesis
- Macroautophagy
- Programmed Cell Death
- Cell Cycle
- Regulation Of Autophagy
- Cell Proliferation
- Cell Growth
- Rna Interference
- Cell Cycle Arrest
- Catabolic Process
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Methylation
- Dephosphorylation
- Reduction
Research Areas
- Apoptosis
- Autophagy
- Cancer
- HIF Target Genes
- Hypoxia
- Immunology
- Innate Immunity
- mTOR Pathway
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BECN1
bosterbio.com/bosterbio-gene-info-cards/BECN1
References
PMID: 9765397 by Liang X.H., et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein.
PMID: 10395800 by Aita V.M., et al. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21.
17 Publications of Boster Beclin-1 Antibodies & ELISA Kits
- PubMed ID: PMID:27293989, Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in...
- PubMed ID: 10.3892/ijo.2015.3039, Autophagy is involved in recombinant Newcastle disease virus (rL-RVG)-induced ce...
- PubMed ID: 10.3390/toxins13070503, The Protein-Independent Role of Phosphate in the Progression of Chronic Kidney D...
- PubMed ID: 10.1155/2021/5584447, Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyr...
- PubMed ID: 10.1007/s12288-019-01241-3, MicroRNA 30a Mediated Autophagy and Imatinib Response in Egyptian Chronic Myeloi...
- PubMed ID: 10.1002/iub.2539, Endogenous dipeptide-carnosine supplementation ameliorates hypobaric hypoxia-ind...
- PubMed ID: -, Gang Zhong,Huiping Long,Shiting Ma,Yao Shunhan,Jia Li,Jun Yao,miRNA-335-5p relie...
- PubMed ID: -, Zhiwei Liao,Suyun Li,Rong Liu,Xiaobo Feng,Yunsong Shi,Kun Wang,Shuai Li,Yukun Zh...
- PubMed ID: 33529908, Ni K,Hua Y.Hydrogen sulfide exacerbated periodontal inflammation and induced aut...
- PubMed ID: 31900522, Song L,Yao L,Zhang L,Piao Z,Lu Y.Schizandrol A protects against Aβ1-42-induced ...
- PubMed ID: 30016968, Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of c...
- PubMed ID: 28848439, Antagomirs Targeting MiroRNA-134 Attenuates Epilepsy in Rats through Regulation ...
- PubMed ID: 27464624, Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system ind...
- PubMed ID: 27293989, Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in...
- PubMed ID: 29725398, Qi QM, Xue YC, Lv J, Sun D, Du JX, Cai SQ, Li YH, Gu TC, Wang MB. Oncol Lett. 20...
- PubMed ID: 29651246, Wang G, Dai G, Song J, Zhu M, Liu Y, Hou X, Ke Z, Zhou Y, Qiu H, Wang F, Jiang N...
- PubMed ID: 29052054, Song J, Hu Y, Li J, Zheng H, Wang J, Guo L, Shi H, Liu L. Arch Virol. 2018 Jan;1...
*More publications can be found for each product on its corresponding product page