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- Table of Contents
Cathepsin D Antibodies
AND CTSD ELISA kits, Cathepsin D Proteins
Many biological assays use antibodies to detect Cathepsin D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cathepsin D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cathepsin D antibodies...
Designing a Western blot for Cathepsin D? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CTSD Western Blot GuideCTSD Infographic by Boster Bio
All CTSD Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$450
Cat # EK0672
96 wells/kit, with removable strips.
Cat # EK0672
96 wells/kit, with removable strips.
Anti-Cathepsin D/CTSD Antibody Picoband®
1 Citations
Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # PB9048
100 μg/vial
Cat # PB9048
100 μg/vial
Mouse
ELISA
$499
Cat # EK0673
96 wells/kit, with removable strips.
Cat # EK0673
96 wells/kit, with removable strips.
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9854
100 μg/vial
Cat # PB9854
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01361
100 μl
Cat # M01361
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01361-1
20μL, 40μL, 100μL, 200μL
Cat # M01361-1
20μL, 40μL, 100μL, 200μL
Enzyme Activity, SDS-PAGE
$265
Cat # PROTP18242
Starting from 5ug
Cat # PROTP18242
Starting from 5ug
CTSD Overview
Facts about Cathepsin D.
Cathepsin D (CTSD)
Acid protease active in intracellular protein breakdown. Plays a role in APP processing after cleavage and activation by ADAM30 which contributes to APP degradation (PubMed:27333034).
Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CTSD |
| Uniprot: | P07339 |
| Entrez: | 1509 |
Family
| Belongs to: |
|---|
| peptidase A1 family |
Alternative Names
cathepsin D (lysosomal aspartyl protease); Cathepsin D; CPSD; CTSD; EC 3.4.23; EC 3.4.23.5; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311; neuronal 10
Molecular Weight
Mass (kDA):
44.552 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.5 |
| Sequence: | 11; NC_000011.10 (1752755..1763927, complement) |
Tissue Specificity
Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).
Subcellular Localizations
Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).
Diseases
- Malignant Neoplasms
- Neoplasms
- Alzheimer's Disease
- Carcinoma
- Neuronal Ceroid-lipofuscinoses
- Cell Invasion
- Inflammation
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Neoplasm Metastasis
- Nerve Degeneration
- Tissue Adhesions
Interacting Proteins
- APP
Pathways
- Pathogenesis
- Cell Death
- Autophagy
- Secretion
- Proteolysis
- Localization
- Cell Proliferation
- Cell Cycle
- Cell Adhesion
- Transport
- Reverse Transcription
- Spermatogenesis
- Aging
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTSD
bosterbio.com/bosterbio-gene-info-cards/CTSD
References
PMID: 3927292 by Faust P.L., et al. Cloning and sequence analysis of cDNA for human cathepsin D.
PMID: 3588310 by Westley B.R., et al. Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells.
3 Publications of Boster Cathepsin D Antibodies & ELISA Kits
- PubMed ID: 33203874, Ma WQ,Sun XJ,Zhu Y,Liu NF. PDK4 promotes vascular calcification by interfering w...
- PubMed ID: 27310928, Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-...
- PubMed ID: 29375176, Liu L, Chen B, Zhang X, Tan L, Wang DW. Dis Markers. 2017;2017:5286408. doi: 10....
*More publications can be found for each product on its corresponding product page