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3 Citations
Facts about Low affinity immunoglobulin gamma Fc region receptor II.
Involved in many different effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis.
| Mouse | |
|---|---|
| Gene Name: | Fcgr2 |
| Uniprot: | P08101 |
| Entrez: | |

| Belongs to: |
|---|
| No superfamily |

Low affinity immunoglobulin gamma Fc region receptor II
Mass (kDA):
36.695 kDA

| Mouse | |
|---|---|
| Location: | |
| Sequence: | ; |
Widely expressed by cells of hemopoietic origin. The isoforms are differentially expressed. Isoform IIB1 is preferentially expressed by cells of the lymphoid lineage, isoform IIB2 by cells of the myeloid lineage, and isoform IIB3 is released by macrophages and is present in the serum. Isoform IIB1' is expressed in myeloid and lymphoid cell lines, in normal spleen cells, and in resting or LPS-activated B-cells but is not detected in mesenteric lymph node cells.

PMID: 2946078 by Ravetch J.V., et al. Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors.
PMID: 3024012 by Lewis V.A., et al. A complementary DNA clone for a macrophage-lymphocyte Fc receptor.
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