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- Table of Contents
Granzyme B Antibodies
AND GZMB ELISA kits, Granzyme B Proteins
Many biological assays use antibodies to detect Granzyme B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Granzyme B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Granzyme B antibodies...
Designing an IHC experiment for Granzyme B? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the GZMB IHC GuideGZMB Infographic by Boster Bio
All GZMB Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$499
Cat # EK1115
96 wells/kit, with removable strips.
Cat # EK1115
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # EK1114
96 wells/kit, with removable strips.
Cat # EK1114
96 wells/kit, with removable strips.
Human
ELISA, IP, IF, IHC, WB
$146
Cat # M00353-3
20μL, 40μL, 100μL, 200μL
Cat # M00353-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$480
Cat # EKC1249
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1249
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
IHC, WB
$370
Cat # M00353-4
100 μl/vial
Cat # M00353-4
100 μl/vial
Enzyme Activity, SDS-PAGE
$275
Cat # PROTP10144
Starting from 10ug
Cat # PROTP10144
Starting from 10ug
GZMB Overview
Facts about Granzyme B.
Granzyme B (GZMB)
This enzyme is essential for target cell lysis in cell- mediated immune reactions. It cleaves after Asp.
Appears to be connected to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to contribute to active enzymes mediating apoptosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | GZMB |
| Uniprot: | P10144 |
| Entrez: | 3002 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; CTLA1; CTLA-1; CTSGL1; Fragmentin-2; Granzyme B; Granzyme-2; GRB; GrzB; GZMB; HLP; SECT
Molecular Weight
Mass (kDA):
27.716 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q12 |
| Sequence: | 14; NC_000014.9 (24630954..24634190, complement) |
Subcellular Localizations
Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
Diseases
- Neoplasms
- Malignant Neoplasms
- Lymphoma
- Virus Diseases
- Carcinoma
- Infective Disorder
- Leukemia
- T-cell Lymphoma
- Autoimmune Reaction
- Inflammation
- Cytomegalovirus Infections
- Autoimmune Diseases
- Graft-vs-host Disease
Interacting Proteins
- PRF1
- SRGN
Pathways
- Cell Death
- Immune Response
- Exocytosis
- Pathogenesis
- Induction Of Apoptosis
- Secretion
- Localization
- Cell Activation
- Proteolysis
- Cell Killing
- Cytolysis
- Programmed Cell Death
- T Cell Activation
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GZMB
bosterbio.com/bosterbio-gene-info-cards/GZMB
References
PMID: 2953813 by Schmid J., et al. Induction of mRNA for a serine protease and a beta-thromboglobulin- like protein in mitogen-stimulated human leukocytes.
PMID: 3258865 by Caputo A., et al. Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes.