IL12A Antibodies

Interleukin-12 subunit alpha (IL12A)

Cytokine that can serve as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated Killer cells, and stimulate the creation of IFN-gamma by resting PBMC. .

Gene Information

Human
Gene Name:	IL12A
Uniprot:	P29459
Entrez:	3592

Family

Belongs to:
IL-6 superfamily

Alternative Names

CLMF p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL12 p70; IL-12 p70; IL-12 subunit p35; IL-12, subunit p35; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35); interleukin-12 alpha chain; interleukin-12 subunit alpha; natural killer cell stimulatory factor 1, 35 kD subunit; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; NKSF1; p35

Molecular Weight

Mass (kDA):
24.874 kDA

Genomic Context

Human
Location:	3q25.33
Sequence:	3; NC_000003.12 (159988835..159996019)

Subcellular Localizations

Secreted.

Diseases

• Malignant Neoplasms
• Neoplasms
• Autoimmune Reaction
• Inflammation
• Infective Disorder
• Autoimmune Diseases
• Celiac Disease
• Sclerosis
• Multiple Sclerosis
• Lymphoma
• Primary Biliary Cirrhosis
• Biliary Cirrhosis
• Liver Cirrhosis

• Carcinoma
• Lymphoma, Non-hodgkin
• Cholangiocarcinoma
• Virus Diseases
• Autoimmunity
• Dysequilibrium Syndrome
• Diabetes Mellitus

Interacting Proteins

• IL12B

Pathways

• Immune Response
• Pathogenesis
• Secretion
• Inflammatory Response
• Reverse Transcription
• Cytokine Production
• Cell Proliferation
• Localization
• Response To Lipopolysaccharide
• Cell Activation
• Cytokine Secretion
• Virulence
• Cell Differentiation

• Innate Immune Response
• Cell Development
• Cell Death
• Rna Interference
• Excretion
• Gene Silencing
• T Cell Activation

PTMs

• Phosphorylation

• Deacetylation

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL12A

Boster Bio: Best Uses Of The IL12A Marker

This article will discuss the Boster Bio: Il12A Marker applications. We will also talk about the quality, price, as well as cost. These are the most important questions to ask when looking to purchase a product. The following information will help you choose the Boster Biz IL12A Marker.

Boster Bio: IL12A marker

Antibodies that recognize IL12A proteins can be used to determine your IL12A markers. Boster Bio offers antibodies that react with mouse, human, or rat samples. In addition to antibodies, Boster also offers blocking peptides. This means that you can employ one antibody to analyze thousands of cells. The best way to purchase these antibodies is through Boster Bio.

Applications

One of the many advantages of the IL-12A the cytokine marker is its ability to predict a patient's response to CAR–T therapy. The cytokine can boost the anti-tumor immune response. It is of limited therapeutic value and tumor-specific T-cell secretion restricts its use to tumors. Additionally, single-chain versions of IL-12 released by TILs with a NFAT-response promoter have been linked to significant toxicities.

IL-12A is produced by macrophages in response infectious agents, including viruses. It is a key mediator of the immune cell system and can increase the activity and growth of TH2 cells. It also inhibits IFN-g production as part of an IL-4-mediated IL lna. Therefore, the uses of the IL12A marker are numerous, and include research into immune responses to pathogens caused by microbial, viral infections, and metastatic cancers.

Researchers from the Chinese Han population studied the role of IL12A in development of PBC in an upcoming study. They enrolled more than 1200 PBC patients and aged-matched controls. They then selected 22 SNPs based on the haplotype structure of CHB samples from the HapMap Project. These genetic variants were associated with the IL12A gene region and were associated with the risk for PBC in Chinese Han individuals.

It is vital to identify the genetic IL12A gene mutation to create targeted treatments for patients suffering from cancer. It is not easy to identify the specific gene responsible for a particular cancer. However it has been established to play an important role in gastric carcinogenesis in H. Pylori infections. It is still controversial to determine the function of the IL12A polymorphisms in causing and growth of gastric cancer. However there is a need for more research to confirm this relationship.

Quality

The IL12A marker is a potent and simple method of detecting cell-mediated signals. The IL12A gene, which is a very common marker of immune cells is vital to study the way that the immune system responds to various stimuli. It can be utilized by researchers to determine the activity of IL-32, one of the signaling proteins. Boster Bio offers high-affinity primary antibodies that are validated by Western Blotting, Immunohistochemistry, and ELISA.

Cost

The IL12A gene is involved in the creation of a TH-1 immunoresponse which is a type of autoimmune response. This type of response includes delayed-type hypersensitivity and cell-mediated immune. The IL-12 protein also plays a part in the regulation and growth of cells. Researchers are still concerned about its expense. This marker may provide more precise diagnosis than what its name implies.